SIRT3 Controls Cancer Metabolic Reprogramming by Regulating ROS and HIF

Paul T. Schumacker

doi:10.1016/j.ccr.2011.03.001

SIRT3 Controls Cancer Metabolic Reprogramming by Regulating ROS and HIF

Paul T. Schumacker^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Short survey

45 Scopus citations

Abstract

In this issue of Cancer Cell, Finley and coworkers report that the genetic loss of the deacetylase SIRT3 leads to metabolic reprogramming toward glycolysis. This shift is mediated by an increase in cellular reactive oxygen species (ROS) generation that amplifies HIF-α stabilization and HIF-dependent gene expression, thereby driving the tumor phenotype.

Original language	English (US)
Pages (from-to)	299-300
Number of pages	2
Journal	Cancer Cell
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/j.ccr.2011.03.001
State	Published - Mar 8 2011

ASJC Scopus subject areas

Oncology
Cell Biology
Cancer Research

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Schumacker, P. T. (2011). SIRT3 Controls Cancer Metabolic Reprogramming by Regulating ROS and HIF. Cancer Cell, 19(3), 299-300. https://doi.org/10.1016/j.ccr.2011.03.001

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