SIRT3 Controls Cancer Metabolic Reprogramming by Regulating ROS and HIF

Paul T. Schumacker*

*Corresponding author for this work

Research output: Contribution to journalShort survey

45 Scopus citations

Abstract

In this issue of Cancer Cell, Finley and coworkers report that the genetic loss of the deacetylase SIRT3 leads to metabolic reprogramming toward glycolysis. This shift is mediated by an increase in cellular reactive oxygen species (ROS) generation that amplifies HIF-α stabilization and HIF-dependent gene expression, thereby driving the tumor phenotype.

Original languageEnglish (US)
Pages (from-to)299-300
Number of pages2
JournalCancer Cell
Volume19
Issue number3
DOIs
StatePublished - Mar 8 2011

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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