Sirtuin 1 in immune regulation and autoimmunity

Sinyi Kong, Michael W. McBurney, Deyu Fang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

51 Scopus citations

Abstract

The NAD-dependent histone deacetylase sirtuin (Sirt)1 is implicated in a wide variety of physiological processes, ranging from tumorigenesis to mitochondrial biogenesis to neuronal development. Recent studies indicate that Sirt1 is a critical regulator of both the innate and adaptive immune response in mice and its altered functions are likely involved in autoimmune diseases. Small molecules that modulate Sirt1 functions are potential therapeutic reagents for autoimmune inflammatory diseases. In this review, we highlight the functions of Sirt1 in the immune system focusing on the underlying molecular mechanisms, and the potential of Sirt1 as a therapeutic target for autoimmune diseases.

Original languageEnglish (US)
Pages (from-to)6-13
Number of pages8
JournalImmunology and Cell Biology
Volume90
Issue number1
DOIs
StatePublished - Jan 1 2012

Keywords

  • T-cell activation
  • autoimmunity
  • sirt1
  • tolerance

ASJC Scopus subject areas

  • Immunology
  • Cell Biology

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