Sister chromatid exchange analysis of human cells exposed to diagnostic levels of ultrasound

A. O. Martin, E. L. Madsen, A. R. Dyer, L. White, N. P. Bouck, R. E. Sabbagha, M. Hermanoff, J. M. Chen, L. J. Ludtke

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Lymphocyte and lymphoblastoid cells were exposed in vitro to diagnostic levels of ultrasonic beams delivered by a Hewlett-Packard CE 30001 and a GE system with a 5 MHz linear transducer for 20 sec, 1 min, 5 min, and 20 min. Temperature and cavitation effects were controlled and there were matched sham exposures. The synergistic effects of theophylline with ultrasonography also were investigated. Small increases in sister chromatid exchange levels were observed after ultrasonic exposure, but increases were so small as to be unlikely to have clinical relevance. Theophylline was found to have no effect and ultrasonography had no effect on cell viability.

Original languageEnglish (US)
Pages (from-to)665-670
Number of pages6
JournalJournal of Ultrasound in Medicine
Volume10
Issue number12
DOIs
StatePublished - 1991

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

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