Six2 activity is required for the formation of the mammalian pyloric sphincter

Michelle Self, Xin Geng, Guillermo Oliver*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The functional activity of Six2, a member of the so/Six family of homeodomain-containing transcription factors, is required during mammalian kidney organogenesis. We have now determined that Six2 activity is also necessary for the formation of the pyloric sphincter, the functional gate at the stomach-duodenum junction that inhibits duodenogastric reflux. Our data reveal that several genes known to be important for pyloric sphincter formation in the chick (e.g., Bmp4, Bmpr1b, Nkx2.5, Sox9, and Gremlin) also appear to be required for the formation of this structure in mammals. Thus, we propose that Six2 activity regulates this gene network during the genesis of the pyloric sphincter in the mouse.

Original languageEnglish (US)
Pages (from-to)409-417
Number of pages9
JournalDevelopmental Biology
Issue number2
StatePublished - Oct 15 2009


  • Mouse
  • Pyloric sphincter
  • Six2
  • Stomach development

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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