Six2 functions redundantly immediately downstream of Hoxa2

Eva Kutejova, Bettina Engist, Michelle Self, Guillermo Oliver, Pavel Kirilenko, Nicoletta Bobola*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Hox transcription factors control morphogenesis along the head-tail axis of bilaterians. Because their direct functional targets are still poorly understood in vertebrates, it remains unclear how the positional information encoded by Hox genes is translated into morphogenetic changes. Here, we conclusively demonstrate that Six2 is a direct downstream target of Hoxa2 in vivo and show that the ectopic expression of Six2, observed in the absence of Hoxa2, contributes to the Hoxa2 mouse mutant phenotype. We propose that Six2 acts to mediate Hoxa2 control over the insulin-like growth factor pathway during branchial arch development.

Original languageEnglish (US)
Pages (from-to)1463-1470
Number of pages8
JournalDevelopment
Volume135
Issue number8
DOIs
StatePublished - Apr 2008

Keywords

  • Branchial arch
  • Hoxa2
  • Mouse
  • Six2

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

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