Six3 is required for ependymal cell maturation

Alfonso Lavado, Guillermo Oliver*

*Corresponding author for this work

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Ependymal cells are part of the neurogenic niche in the adult subventricular zone of the lateral ventricles, where they regulate neurogenesis and neuroblast migration. Ependymal cells are generated from radial glia cells during embryonic brain development and acquire their final characteristics postnatally. The homeobox gene Six3 is expressed in ependymal cells during the formation of the lateral wall of the lateral ventricles in the brain. Here, we show that Six3 is necessary for ependymal cell maturation during postnatal stages of brain development. In its absence, ependymal cells fail to suppress radial glia characteristics, resulting in a defective lateral wall, abnormal neuroblast migration and differentiation, and hydrocephaly.

Original languageEnglish (US)
Pages (from-to)5291-5300
Number of pages10
JournalDevelopment
Volume138
Issue number24
DOIs
StatePublished - Dec 15 2011

Keywords

  • Ependymal cells
  • Mouse
  • Six3
  • Subventricular zone

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Six3 is required for ependymal cell maturation'. Together they form a unique fingerprint.

  • Cite this