Size control of arsenic trioxide nanocrystals grown in nanowells

Eun Ah You; Richard W. Ahn; Hyung Lee Min; Meera R. Raja; Thomas V. O'Halloran; Teri W. Odom

doi:10.1021/ja902117b

Size control of arsenic trioxide nanocrystals grown in nanowells

Eun Ah You, Richard W. Ahn, Hyung Lee Min, Meera R. Raja, Thomas V. O'Halloran, Teri W. Odom

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

(Figure Presented) This paper describes a new strategy to generate nanocrystalline drugs through the precipitation of drug molecules in attoliter nanowells. We controlled the size of arsenic trioxide (ATO) nanocrystals by simply changing the concentration of ATO solution in the nanowells; particles with sizes ranging from 55 to 175 nm were formed. This approach only requires the drugs to be soluble in a solvent and thus can be broadly applicable to produce other drugs in nanocrystalline form.

Original language	English (US)
Pages (from-to)	10863-10865
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	131
Issue number	31
DOIs	https://doi.org/10.1021/ja902117b
State	Published - Aug 12 2009

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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abstract = "(Figure Presented) This paper describes a new strategy to generate nanocrystalline drugs through the precipitation of drug molecules in attoliter nanowells. We controlled the size of arsenic trioxide (ATO) nanocrystals by simply changing the concentration of ATO solution in the nanowells; particles with sizes ranging from 55 to 175 nm were formed. This approach only requires the drugs to be soluble in a solvent and thus can be broadly applicable to produce other drugs in nanocrystalline form.",

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AU - You, Eun Ah

AU - Ahn, Richard W.

AU - Min, Hyung Lee

AU - Raja, Meera R.

AU - O'Halloran, Thomas V.

AU - Odom, Teri W.

PY - 2009/8/12

Y1 - 2009/8/12

N2 - (Figure Presented) This paper describes a new strategy to generate nanocrystalline drugs through the precipitation of drug molecules in attoliter nanowells. We controlled the size of arsenic trioxide (ATO) nanocrystals by simply changing the concentration of ATO solution in the nanowells; particles with sizes ranging from 55 to 175 nm were formed. This approach only requires the drugs to be soluble in a solvent and thus can be broadly applicable to produce other drugs in nanocrystalline form.

AB - (Figure Presented) This paper describes a new strategy to generate nanocrystalline drugs through the precipitation of drug molecules in attoliter nanowells. We controlled the size of arsenic trioxide (ATO) nanocrystals by simply changing the concentration of ATO solution in the nanowells; particles with sizes ranging from 55 to 175 nm were formed. This approach only requires the drugs to be soluble in a solvent and thus can be broadly applicable to produce other drugs in nanocrystalline form.

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Size control of arsenic trioxide nanocrystals grown in nanowells

Abstract

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