Skeletal demineralization in Turner's syndrome

Richard M. Shore, Russell W. Chesney, Richard B. Mazess, Philip G. Rose, Gerald J. Bargman*

*Corresponding author for this work

Research output: Contribution to journalArticle

86 Scopus citations

Abstract

The bone mineral status of 17 girls with Turner's syndrome was evaluated by single photon absorptiometry. Bone mineral content (BMC) was 25.4% below that predicted by normalization for age, sex, height, weight, and bone width. Only 25% of this demineralization could be attributed to delayed skeletal maturation. Bones of girls who received estrogen replacement therapy were less demineralized than those of the others. The bone mineral deficit became less pronounced with advancing age. It could not be determined if the apparent effect of estrogens was related to age or if the apparent improvement with age was really due to an effect of estrogen treatment. For 8 subjects followed longitudinally there was no significant change in the BMC deficit.

Original languageEnglish (US)
Pages (from-to)519-522
Number of pages4
JournalCalcified Tissue International
Volume34
Issue number1
DOIs
StatePublished - Dec 1 1982

Keywords

  • Bone
  • Osteoporosis
  • Ovarian dysgenesis
  • Turner's syndrome

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

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    Shore, R. M., Chesney, R. W., Mazess, R. B., Rose, P. G., & Bargman, G. J. (1982). Skeletal demineralization in Turner's syndrome. Calcified Tissue International, 34(1), 519-522. https://doi.org/10.1007/BF02411296