Skeletal muscle fiber-type specific succinate dehydrogenase activity in cerebral palsy

Andrew M. Zogby, Sudarshan Dayanidhi, Henry G. Chambers, Simon Schenk, Richard L. Lieber*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Introduction: Children with cerebral palsy (CP) exhibit increased energy expenditure during movement, but whether this is due in part to decrements in skeletal muscle mitochondrial oxidative capacity is unknown. Accordingly, we compared fiber-type specific succinate dehydrogenase (SDH) activity in children with CP with typically developing (TD) children. Methods: SDH activity and myofiber areas of type 1 and 2A fibers were measured in semitendinosus biopsies of both groups (n = 5/group). Results: SDH activity was ∼35% higher in type 1 compared with type 2A fibers, but there were no differences between groups. Average myofiber area was 45% smaller in CP versus TD (P < 0.05), and type 2A fibers were 32% larger than type 1 fibers (P < 0.05) only in TD children. Conclusions: Fiber-type specific SDH activity is similar between TD children and children with CP. This suggests that increased energy expenditure in children with CP is not related to impaired mitochondrial oxidative capacity. Muscle Nerve, 2016 Muscle Nerve 55: 122–124, 2017.

Original languageEnglish (US)
Pages (from-to)122-124
Number of pages3
JournalMuscle and Nerve
Volume55
Issue number1
DOIs
StatePublished - Jan 1 2017

Keywords

  • cerebral palsy
  • energy expenditure
  • fiber type
  • oxidative capacity
  • skeletal muscle
  • succinate dehydrogenase

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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