Skeletal muscle Na+ channel disorders

Dina Simkin, Saïd Bendahhou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

Five inherited human disorders affecting skeletal muscle contraction have been traced to mutations in the gene encoding the voltage-gated sodium channel Nav1.4.The main symptoms of these disorders are myotonia or periodic paralysis caused by changes in skeletal muscle fiber excitability. Symptoms of these disorders vary from mild or latent disease to incapacitating or even death in severe cases. As new human sodium channel mutations corresponding to disease states become discovered, the importance of understanding the role of the sodium channel in skeletal muscle function and disease state grows.

Original languageEnglish (US)
Article numberArticle 63
JournalFrontiers in Pharmacology
VolumeOCT
DOIs
StatePublished - 2011
Externally publishedYes

Keywords

  • Na1.4
  • Skeletal muscle
  • Sodium channel
  • Treatment

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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