Skeletal muscle response to tenotomy

Amir A. Jamali, Pouya Afshar, Reid A. Abrams, Richard L. Lieber*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations

Abstract

Tenotomy is a commonly encountered clinical entity, whether traumatic or iatrogenic. This article reviews the response of skeletal muscle to tenotomy. The changes are subdivided into molecular, architectural, and functional categories. Architectural disruption of the muscle includes myofiber disorganization, central core necrosis, Z-line streaming; fibrosis of fibers and Golgi tendon organs, changes in sarcomere number, and alterations in the number of membrane particles. Molecular changes include transient changes in myosin heavy chain composition and expression of neural cell adhesion molecule (NCAM). Functionally, tenotomized muscle produces decreased maximum tetanic and twitch tension. Alterations in normal skeletal muscle structure and function are clinically applicable to the understanding of pathological states that follow tendon rupture and iatrogenic tenotomy. (C) 2000 John Wiley and Sons, Inc.

Original languageEnglish (US)
Pages (from-to)851-862
Number of pages12
JournalMuscle and Nerve
Volume23
Issue number6
DOIs
StatePublished - Jun 26 2000

Keywords

  • Immobilization
  • Muscle injury
  • Muscle mechanics
  • Sarcomere number
  • Surgical tendon transfer
  • Tenotomy

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Fingerprint Dive into the research topics of 'Skeletal muscle response to tenotomy'. Together they form a unique fingerprint.

Cite this