Skeletal muscle satellite cells: Mediators of muscle growth during development and implications for developmental disorders

Sudarshan Dayanidhi, Richard L. Lieber*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations

Abstract

Satellite cells (SCs) are the muscle stem cells responsible for longitudinal and cross-sectional postnatal growth and repair after injury and which provide new myonuclei when needed. We review their morphology and contribution to development and their role in sarcomere and myonuclear addition. SCs, similar to other tissue stem cells, cycle through different states, such as quiescence, activation, and self-renewal, and thus we consider the signaling mechanisms involved in maintenance of these states. The role of the SC niche and their interactions with other cells, such as fibroblasts and the extracellular matrix, are all emerging as major factors that affect aging and disease. Interestingly, children with cerebral palsy appear to have a reduced SC number, which could play a role in their reduced muscular development and even in muscular contracture formation. Finally, we review the current information on SC dysfunction in children with muscular dystrophy and emerging therapies that target promotion of myogenesis and reduction of fibrosis.

Original languageEnglish (US)
Pages (from-to)723-732
Number of pages10
JournalMuscle and Nerve
Volume50
Issue number5
DOIs
StatePublished - Nov 1 2014

Keywords

  • Cerebral palsy
  • Muscle stem cells
  • Myonuclei
  • Postnatal development
  • Satellite cells

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

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