Skin as the primary site of Hodgkin's disease: A case report of primary cutaneous Hodgkin's disease and review of its relationship with non-Hodgkin's lymphoma

Joan Guitart*, David Fretzin

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

We report an elderly patient who presented with a single cutaneous nodule of primary cutaneous Hodgkin's disease (PCHD). Reed-Sternberg cells, expressing CD30 and CD15, but not leukocyte common antigen (CD45RB), were identified in the neoplastic cells. Southern blot analysis failed to detect T-cell receptor or immunoglobulin gene rearrangement. A work-up for systemic disease at the time of presentation was negative, supporting the diagnosis of PCHD. Nevertheless, 1 year later, the disease course was complicated by the development of nodal HD and nonHodgkin's lymphoma (NHL). This case report supports the existence of this rare, but distinct, cutaneous tumor.

Original languageEnglish (US)
Pages (from-to)218-222
Number of pages5
JournalAmerican Journal of Dermatopathology
Volume20
Issue number2
DOIs
StatePublished - Apr 23 1998

Keywords

  • Hodgkin's disease
  • Reed-Sternberg cells
  • Skin

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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