Skin-interfaced biosensors for advanced wireless physiological monitoring in neonatal and pediatric intensive-care units

Ha Uk Chung, Alina Y. Rwei, Aurélie Hourlier-Fargette, Shuai Xu, Kun Hyuck Lee, Emma C. Dunne, Zhaoqian Xie, Claire Liu, Andrea Carlini, Dong Hyun Kim, Dennis Ryu, Elena Kulikova, Jingyue Cao, Ian C. Odland, Kelsey B. Fields, Brad Hopkins, Anthony Banks, Christopher Ogle, Dominic Grande, Jun Bin ParkJongwon Kim, Masahiro Irie, Hokyung Jang, Joo Hee Lee, Yerim Park, Jungwoo Kim, Han Heul Jo, Hyoungjo Hahm, Raudel Avila, Yeshou Xu, Myeong Namkoong, Jean Won Kwak, Emily Suen, Max A. Paulus, Robin J. Kim, Blake V. Parsons, Kelia A. Human, Seung Sik Kim, Manish Patel, William Reuther, Hyun Soo Kim, Sung Hoon Lee, John D. Leedle, Yeojeong Yun, Sarah Rigali, Taeyoung Son, Inhwa Jung, Hany Arafa, Vinaya R. Soundararajan, Ayelet Ollech, Avani Shukla, Allison Bradley, Molly Schau, Casey M. Rand, Lauren E. Marsillio, Zena L. Harris, Yonggang Huang, Aaron Hamvas, Amy S. Paller, Debra E. Weese-Mayer, Jong Yoon Lee*, John A. Rogers

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

190 Scopus citations


Standard clinical care in neonatal and pediatric intensive-care units (NICUs and PICUs, respectively) involves continuous monitoring of vital signs with hard-wired devices that adhere to the skin and, in certain instances, can involve catheter-based pressure sensors inserted into the arteries. These systems entail risks of causing iatrogenic skin injuries, complicating clinical care and impeding skin-to-skin contact between parent and child. Here we present a wireless, non-invasive technology that not only offers measurement equivalency to existing clinical standards for heart rate, respiration rate, temperature and blood oxygenation, but also provides a range of important additional features, as supported by data from pilot clinical studies in both the NICU and PICU. These new modalities include tracking movements and body orientation, quantifying the physiological benefits of skin-to-skin care, capturing acoustic signatures of cardiac activity, recording vocal biomarkers associated with tonality and temporal characteristics of crying and monitoring a reliable surrogate for systolic blood pressure. These platforms have the potential to substantially enhance the quality of neonatal and pediatric critical care.

Original languageEnglish (US)
Pages (from-to)418-429
Number of pages12
JournalNature Medicine
Issue number3
StatePublished - Mar 1 2020

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


Dive into the research topics of 'Skin-interfaced biosensors for advanced wireless physiological monitoring in neonatal and pediatric intensive-care units'. Together they form a unique fingerprint.

Cite this