@article{42e1266f390040e8a99d92392d78b54d,
title = "Skin-interfaced biosensors for advanced wireless physiological monitoring in neonatal and pediatric intensive-care units",
abstract = "Standard clinical care in neonatal and pediatric intensive-care units (NICUs and PICUs, respectively) involves continuous monitoring of vital signs with hard-wired devices that adhere to the skin and, in certain instances, can involve catheter-based pressure sensors inserted into the arteries. These systems entail risks of causing iatrogenic skin injuries, complicating clinical care and impeding skin-to-skin contact between parent and child. Here we present a wireless, non-invasive technology that not only offers measurement equivalency to existing clinical standards for heart rate, respiration rate, temperature and blood oxygenation, but also provides a range of important additional features, as supported by data from pilot clinical studies in both the NICU and PICU. These new modalities include tracking movements and body orientation, quantifying the physiological benefits of skin-to-skin care, capturing acoustic signatures of cardiac activity, recording vocal biomarkers associated with tonality and temporal characteristics of crying and monitoring a reliable surrogate for systolic blood pressure. These platforms have the potential to substantially enhance the quality of neonatal and pediatric critical care.",
author = "Chung, {Ha Uk} and Rwei, {Alina Y.} and Aur{\'e}lie Hourlier-Fargette and Shuai Xu and Lee, {Kun Hyuck} and Dunne, {Emma C.} and Zhaoqian Xie and Claire Liu and Andrea Carlini and Kim, {Dong Hyun} and Dennis Ryu and Elena Kulikova and Jingyue Cao and Odland, {Ian C.} and Fields, {Kelsey B.} and Brad Hopkins and Anthony Banks and Christopher Ogle and Dominic Grande and Park, {Jun Bin} and Jongwon Kim and Masahiro Irie and Hokyung Jang and Lee, {Joo Hee} and Yerim Park and Jungwoo Kim and Jo, {Han Heul} and Hyoungjo Hahm and Raudel Avila and Yeshou Xu and Myeong Namkoong and Kwak, {Jean Won} and Emily Suen and Paulus, {Max A.} and Kim, {Robin J.} and Parsons, {Blake V.} and Human, {Kelia A.} and Kim, {Seung Sik} and Manish Patel and William Reuther and Kim, {Hyun Soo} and Lee, {Sung Hoon} and Leedle, {John D.} and Yeojeong Yun and Sarah Rigali and Taeyoung Son and Inhwa Jung and Hany Arafa and Soundararajan, {Vinaya R.} and Ayelet Ollech and Avani Shukla and Allison Bradley and Molly Schau and Rand, {Casey M.} and Marsillio, {Lauren E.} and Harris, {Zena L.} and Yonggang Huang and Aaron Hamvas and Paller, {Amy S.} and Weese-Mayer, {Debra E.} and Lee, {Jong Yoon} and Rogers, {John A.}",
note = "Funding Information: D.E.W.-M., A.H., C.M.R., R.G. and J.A.R. acknowledge funding from the Bill & Melinda Gates Foundation (OPP1182909). S.X. and J.A.R. acknowledge additional funding from the Bill & Melinda Gates Foundation (OPP1193311). D.E.W.-M., A.H., C.M.R., R.G. and J.A.R. acknowledge support from the Gerber Foundation. A.S.P., D.E.W.-M., A.H. and J.A.R. recognize the Friends of Prentice Foundation for their support. J.A.R. and S.X. also recognize support from Save the Children (award 999002170). A.Y.R. gratefully acknowledges funding support by the National Institutes of Health{\textquoteright}s National Center for Advancing Translational Sciences, grant TL1TR001423. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. E.S. recognizes funding support from the WCAS Undergraduate Research Grant Program, which is administered by Northwestern University{\textquoteright}s Weinberg College of Arts and Sciences. The conclusions, opinions and other statements in this publication are the author{\textquoteright}s and not necessarily those of the sponsoring institution. This work is also supported by the National Natural Science Foundation of China (11402134 and 11320101001), the National Basic Research program of China (2015CB351900) and the National Science Foundation (1400159, 1534120 and 1635443). The materials and engineering efforts were supported by the Center for Bio-Integrated Electronics of the Simpson Querrey Institute at Northwestern University. This work utilized Northwestern University Micro/Nano Fabrication Facility (NUFAB), which is partially supported by Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF ECCS-1542205), the Materials Research Science and Engineering Center (DMR-1720139), the State of Illinois and Northwestern University. Publisher Copyright: {\textcopyright} 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.",
year = "2020",
month = mar,
day = "1",
doi = "10.1038/s41591-020-0792-9",
language = "English (US)",
volume = "26",
pages = "418--429",
journal = "Nature Medicine",
issn = "1078-8956",
publisher = "Nature Publishing Group",
number = "3",
}