Skin-Interfaced Microfluidic System with Machine Learning-Enabled Image Processing of Sweat Biomarkers in Remote Settings

Lindsay B. Baker*, Melissa S. Seib, Kelly A. Barnes, Shyretha D. Brown, Michelle A. King, Peter John D. De Chavez, Shankang Qu, Julian Archer, Anthony S. Wolfe, John R. Stofan, James M. Carter, Donald E. Wright, Jessica Wallace, Da Som Yang, Shanliangzi Liu, John Anderson, Tucker Fort, Weihua Li, John A. Wright, Stephen P. LeeJeffrey B. Model, John A. Rogers, Alexander J. Aranyosi, Roozbeh Ghaffari*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Dehydration has many deleterious effects on cognitive and physical performance as well as physiological function, in the context of sports, industrial work, clinical rehabilitation, and military applications. Because sweat loss and electrolyte loss vary across individuals, conventional sweat testing strategies using absorbent patch techniques are employed in laboratory settings to characterize sweat biomarkers; however, these techniques are not suitable for remote environments. Here, an updated wearable microfluidic sweat testing system targeted for recreational athletes is presented that includes a microfluidic patch accommodating a broad range of sweating rates, and a smartphone app incorporating digital image processing algorithms to enable real-time analysis under different lighting conditions and patch orientations. Expansive field trials (n = 148 subjects) show significant correlations between the microfluidic patch and standard absorbent patch in measuring sweating rate and sweat chloride concentration during recreational exercise. This validation study demonstrates the applicability of the microfluidic patch and software platform for field testing in recreational athletes.

Original languageEnglish (US)
Article number2200249
JournalAdvanced Materials Technologies
Issue number11
StatePublished - Nov 2022


  • electrolytes
  • fitness
  • hydration
  • microfluidics
  • wearables

ASJC Scopus subject areas

  • General Materials Science
  • Mechanics of Materials
  • Industrial and Manufacturing Engineering


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