Sleep and circadian rhythms: Key components in the regulation of energy metabolism

Aaron D. Laposky*, Joseph Bass, Akira Kohsaka, Fred W. Turek

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

222 Scopus citations

Abstract

In this review, we present evidence from human and animal studies to evaluate the hypothesis that sleep and circadian rhythms have direct impacts on energy metabolism, and represent important mechanisms underlying the major health epidemics of obesity and diabetes. The first part of this review will focus on studies that support the idea that sleep loss and obesity are "interacting epidemics." The second part will discuss recent evidence that the circadian clock system plays a fundamental role in energy metabolism at both the behavioral and molecular levels. These lines of research must be seen as in their infancy, but nevertheless, have provided a conceptual and experimental framework that potentially has great importance for understanding metabolic health and disease.

Original languageEnglish (US)
Pages (from-to)142-151
Number of pages10
JournalFEBS Letters
Volume582
Issue number1
DOIs
StatePublished - Jan 9 2008

Keywords

  • Circadian clock genes
  • Circadian rhythms
  • Metabolic syndrome
  • Obesity
  • Sleep
  • Sleep deprivation

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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