Sleep and limb movement characteristics of children with atopic dermatitis coincidentally undergoing clinical polysomnography

Alison D. Treister, Heather Stefek, Daniela Grimaldi, Neil Rupani, Phyllis C Zee, Jeremy Yob, Stephen H Sheldon, Anna Fishbein*

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

Study Objectives: Atopic dermatitis (AD) is a prevalent, chronic, itchy skin condition. Children undergoing polysomnography (PSG) may coincidentally have AD. Many children with AD have sleep disturbances. Our study aimed to characterize limb movements in children with AD and their effect on sleep. Methods: A retrospective chart review was conducted for children who underwent comprehensive attended PSG and had AD. PSG sleep parameters were compared to published normative data. A subset of patients with markedly elevated total limb movements was further compared to a matched group of patients with a diagnosis of periodic limb movement disorder (PLMD) and no history of AD. Results: There were 34 children with AD 6.36 ± 3.21 years (mean ± standard deviation), 50% female and with mild to moderate AD. There was increased wake after sleep onset (WASO = 46.0 ± 37.8 minutes), sleep onset latency (46.5 ± 53.0 minutes) and total limb movement index (13.9 ± 7.5 events/h) compared to normative values. Although our cohort was mostly mild AD, 7 of the 34 children with AD (20%) had a total limb movement index during sleep > 15 events/h. Increased total limb movements in PLMD versus patients with AD was most notable during stage N2 sleep (38 ± 17 versus 22 ± 7, P = .01, respectively). Conclusions: We found altered PSG parameters in children with AD, suggesting that clinicians should consider the diagnosis when affected children undergo PSG. Although our AD cohort was mild, we still determined a need to consider AD when diagnosing PLMD given the presence of elevated total limb movements in children with AD.

Original languageEnglish (US)
Pages (from-to)1107-1113
Number of pages7
JournalJournal of Clinical Sleep Medicine
Volume15
Issue number8
DOIs
StatePublished - Aug 15 2019

Fingerprint

Polysomnography
Atopic Dermatitis
Sleep
Extremities
Nocturnal Myoclonus Syndrome
Sleep Stages

Keywords

  • Atopic dermatitis
  • Periodic limb movements of sleep
  • Polysomnography
  • Pruritus
  • Sleep

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Neurology
  • Clinical Neurology

Cite this

@article{42fca5e8e2534ca68f15a07eaea21998,
title = "Sleep and limb movement characteristics of children with atopic dermatitis coincidentally undergoing clinical polysomnography",
abstract = "Study Objectives: Atopic dermatitis (AD) is a prevalent, chronic, itchy skin condition. Children undergoing polysomnography (PSG) may coincidentally have AD. Many children with AD have sleep disturbances. Our study aimed to characterize limb movements in children with AD and their effect on sleep. Methods: A retrospective chart review was conducted for children who underwent comprehensive attended PSG and had AD. PSG sleep parameters were compared to published normative data. A subset of patients with markedly elevated total limb movements was further compared to a matched group of patients with a diagnosis of periodic limb movement disorder (PLMD) and no history of AD. Results: There were 34 children with AD 6.36 ± 3.21 years (mean ± standard deviation), 50{\%} female and with mild to moderate AD. There was increased wake after sleep onset (WASO = 46.0 ± 37.8 minutes), sleep onset latency (46.5 ± 53.0 minutes) and total limb movement index (13.9 ± 7.5 events/h) compared to normative values. Although our cohort was mostly mild AD, 7 of the 34 children with AD (20{\%}) had a total limb movement index during sleep > 15 events/h. Increased total limb movements in PLMD versus patients with AD was most notable during stage N2 sleep (38 ± 17 versus 22 ± 7, P = .01, respectively). Conclusions: We found altered PSG parameters in children with AD, suggesting that clinicians should consider the diagnosis when affected children undergo PSG. Although our AD cohort was mild, we still determined a need to consider AD when diagnosing PLMD given the presence of elevated total limb movements in children with AD.",
keywords = "Atopic dermatitis, Periodic limb movements of sleep, Polysomnography, Pruritus, Sleep",
author = "Treister, {Alison D.} and Heather Stefek and Daniela Grimaldi and Neil Rupani and Zee, {Phyllis C} and Jeremy Yob and Sheldon, {Stephen H} and Anna Fishbein",
year = "2019",
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day = "15",
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language = "English (US)",
volume = "15",
pages = "1107--1113",
journal = "Journal of Clinical Sleep Medicine",
issn = "1550-9389",
publisher = "American Academy of Sleep Medicine",
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}

Sleep and limb movement characteristics of children with atopic dermatitis coincidentally undergoing clinical polysomnography. / Treister, Alison D.; Stefek, Heather; Grimaldi, Daniela; Rupani, Neil; Zee, Phyllis C; Yob, Jeremy; Sheldon, Stephen H; Fishbein, Anna.

In: Journal of Clinical Sleep Medicine, Vol. 15, No. 8, 15.08.2019, p. 1107-1113.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Sleep and limb movement characteristics of children with atopic dermatitis coincidentally undergoing clinical polysomnography

AU - Treister, Alison D.

AU - Stefek, Heather

AU - Grimaldi, Daniela

AU - Rupani, Neil

AU - Zee, Phyllis C

AU - Yob, Jeremy

AU - Sheldon, Stephen H

AU - Fishbein, Anna

PY - 2019/8/15

Y1 - 2019/8/15

N2 - Study Objectives: Atopic dermatitis (AD) is a prevalent, chronic, itchy skin condition. Children undergoing polysomnography (PSG) may coincidentally have AD. Many children with AD have sleep disturbances. Our study aimed to characterize limb movements in children with AD and their effect on sleep. Methods: A retrospective chart review was conducted for children who underwent comprehensive attended PSG and had AD. PSG sleep parameters were compared to published normative data. A subset of patients with markedly elevated total limb movements was further compared to a matched group of patients with a diagnosis of periodic limb movement disorder (PLMD) and no history of AD. Results: There were 34 children with AD 6.36 ± 3.21 years (mean ± standard deviation), 50% female and with mild to moderate AD. There was increased wake after sleep onset (WASO = 46.0 ± 37.8 minutes), sleep onset latency (46.5 ± 53.0 minutes) and total limb movement index (13.9 ± 7.5 events/h) compared to normative values. Although our cohort was mostly mild AD, 7 of the 34 children with AD (20%) had a total limb movement index during sleep > 15 events/h. Increased total limb movements in PLMD versus patients with AD was most notable during stage N2 sleep (38 ± 17 versus 22 ± 7, P = .01, respectively). Conclusions: We found altered PSG parameters in children with AD, suggesting that clinicians should consider the diagnosis when affected children undergo PSG. Although our AD cohort was mild, we still determined a need to consider AD when diagnosing PLMD given the presence of elevated total limb movements in children with AD.

AB - Study Objectives: Atopic dermatitis (AD) is a prevalent, chronic, itchy skin condition. Children undergoing polysomnography (PSG) may coincidentally have AD. Many children with AD have sleep disturbances. Our study aimed to characterize limb movements in children with AD and their effect on sleep. Methods: A retrospective chart review was conducted for children who underwent comprehensive attended PSG and had AD. PSG sleep parameters were compared to published normative data. A subset of patients with markedly elevated total limb movements was further compared to a matched group of patients with a diagnosis of periodic limb movement disorder (PLMD) and no history of AD. Results: There were 34 children with AD 6.36 ± 3.21 years (mean ± standard deviation), 50% female and with mild to moderate AD. There was increased wake after sleep onset (WASO = 46.0 ± 37.8 minutes), sleep onset latency (46.5 ± 53.0 minutes) and total limb movement index (13.9 ± 7.5 events/h) compared to normative values. Although our cohort was mostly mild AD, 7 of the 34 children with AD (20%) had a total limb movement index during sleep > 15 events/h. Increased total limb movements in PLMD versus patients with AD was most notable during stage N2 sleep (38 ± 17 versus 22 ± 7, P = .01, respectively). Conclusions: We found altered PSG parameters in children with AD, suggesting that clinicians should consider the diagnosis when affected children undergo PSG. Although our AD cohort was mild, we still determined a need to consider AD when diagnosing PLMD given the presence of elevated total limb movements in children with AD.

KW - Atopic dermatitis

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KW - Polysomnography

KW - Pruritus

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