Sleep deprivation and metabolism

Erin C. Hanlon*, Kristen L. Knutson

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations


Rates of overweight and obesity have been progressively increasing along with associated disorders such as type II diabetes and cardiovascular disease. Concurrently, average sleep times have gradually decreased. The present chapter discusses evidence from both epidemiologic and laboratory studies suggesting that sleep deficiency may contribute to the increased prevalence of overweight and obesity, along with type II diabetes and cardiovascular disease. The most likely mechanisms linking insufficient sleep and overweight/obesity lie within the hypothalamic nuclei involved in modulating feeding and waking behaviors and involve dysregulation of peripheral factors that modulate neural activity in these nuclei. Moreover, the findings provide evidence that sleep deficiency does indeed impair glucose metabolism and alters the cross-talk between periphery and brain, favoring excessive food intake. A better understanding of the adverse effects of sleep deficiency on metabolism and the central nervous system control of hunger and appetite may have important implications for public health.

Original languageEnglish (US)
Title of host publicationSleep Deprivation and Disease
Subtitle of host publicationEffects on the Body, Brain and Behavior
PublisherSpringer New York
Number of pages19
ISBN (Electronic)9781461490876
ISBN (Print)1461490863, 9781461490869
StatePublished - Aug 1 2014

ASJC Scopus subject areas

  • Medicine(all)


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