TY - JOUR
T1 - Sleep Disordered Breathing in a High-Risk Cohort Prevalence and Severity across Pregnancy
AU - Facco, Francesca L.
AU - Ouyang, David W.
AU - Zee, Phyllis C.
AU - Grobman, William A.
N1 - Publisher Copyright:
Copyright © 2014 by Thieme Medical Publishers, Inc.
PY - 2014/11/1
Y1 - 2014/11/1
N2 - Objective The objective of this study was to determine the prevalence and incidence of sleep disordered breathing (SDB) in pregnancy among high-risk women. Study Design This was a prospective, observational study. We recruited women with a body mass index (BMI) ≥ 30 kg/m2, chronic hypertension, pregestational diabetes, history of preeclampsia, and/or a twin gestation. Objective assessment of SDB was completed between 6 and 20 weeks and again in the third trimester. SDB was defined as an apnea-hypopnea index (AHI) ≥5, and further grouped into severity categories: mild (5-14.9), moderate (15-29.9) and severe (≥30). Subjects who had a normal AHI at the baseline (AHI < 5), but an abnormal study in the third trimester (AHI ≥5) were classified as having new-onset SDB. Results A total of 128 women were recruited. In early pregnancy 21, 6 and 3% had mild, moderate, or severe SDB, respectively. These frequencies increased to 35, 7, and 5% in the third trimester (p < 0.001). About 27% (n = 34) experienced a worsening of SDB during pregnancy; 26 were cases of new-onset SDB, while the other 8 had SDB in early pregnancy that worsened in severity. The incidence of new-onset SDB was 20%. The majority of these new-onset cases were mild. Conclusions SDB in early pregnancy is common in high-risk women and new-onset SDB occurs in 20% of these women.
AB - Objective The objective of this study was to determine the prevalence and incidence of sleep disordered breathing (SDB) in pregnancy among high-risk women. Study Design This was a prospective, observational study. We recruited women with a body mass index (BMI) ≥ 30 kg/m2, chronic hypertension, pregestational diabetes, history of preeclampsia, and/or a twin gestation. Objective assessment of SDB was completed between 6 and 20 weeks and again in the third trimester. SDB was defined as an apnea-hypopnea index (AHI) ≥5, and further grouped into severity categories: mild (5-14.9), moderate (15-29.9) and severe (≥30). Subjects who had a normal AHI at the baseline (AHI < 5), but an abnormal study in the third trimester (AHI ≥5) were classified as having new-onset SDB. Results A total of 128 women were recruited. In early pregnancy 21, 6 and 3% had mild, moderate, or severe SDB, respectively. These frequencies increased to 35, 7, and 5% in the third trimester (p < 0.001). About 27% (n = 34) experienced a worsening of SDB during pregnancy; 26 were cases of new-onset SDB, while the other 8 had SDB in early pregnancy that worsened in severity. The incidence of new-onset SDB was 20%. The majority of these new-onset cases were mild. Conclusions SDB in early pregnancy is common in high-risk women and new-onset SDB occurs in 20% of these women.
KW - pregnancy
KW - sleep apnea
KW - sleep disordered breathing
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U2 - 10.1055/s-0033-1363768
DO - 10.1055/s-0033-1363768
M3 - Article
C2 - 24515622
AN - SCOPUS:84940900007
SN - 0735-1631
VL - 31
SP - 899
EP - 904
JO - American Journal of Perinatology
JF - American Journal of Perinatology
IS - 10
ER -
