TY - JOUR
T1 - Sleep-disordered breathing symptoms are associated with poorer cognitive function in 5-year-old children
AU - Gottlieb, Daniel J.
AU - Chase, Cynthia
AU - Vezina, Richard M.
AU - Heeren, Timothy C.
AU - Corwin, Michael J.
AU - Auerbach, Sanford H.
AU - Weese-Mayer, Debra E.
AU - Lesko, Samuel M.
PY - 2004/10
Y1 - 2004/10
N2 - Objective To assess the relation of sleep-disordered breathing (SDB) symptoms in children to neurocognitive function. Study design A cross-sectional, population-based study of 205 5-year-old children. A parent-completed questionnaire was used to ascertain SDB symptoms, defined as frequent snoring, loud or noisy breathing during sleep, or witnessed sleep apnea. Polysomnography (PSG) data were available in 85% of children. Standardized neurocognitive tests were administered by a trained psychometrist unaware of the children's SDB status. Children with (n=61) and without SDB symptoms were compared using analysis of variance to adjust for demographic and respiratory health variables. Results Children with SDB symptoms scored significantly lower than those without SDB symptoms on tests of executive function (95.5 vs 99.9 on NEPSY Attention/Executive Core Domain, P=.02; 10.4 vs 11.2 on Wechsler Preschool and Primary Scale of Intelligence, Revised [WPPSI-R] Animal Pegs test, P=.03), memory (96.8 vs 103.0 on NEPSY Memory Domain, P=.02), and general intellectual ability (105.9 vs 111.7 on WPPSI-R Full Scale IQ, P=.02). There were no significant differences on a computerized continuous performance task. These findings persisted when children with PSG evidence of obstructive sleep apnea (OSA) were excluded from analysis. Conclusion Even in the absence of OSA, SDB symptoms are associated with poorer executive function and memory skills and lower general intelligence in 5-year-old children.
AB - Objective To assess the relation of sleep-disordered breathing (SDB) symptoms in children to neurocognitive function. Study design A cross-sectional, population-based study of 205 5-year-old children. A parent-completed questionnaire was used to ascertain SDB symptoms, defined as frequent snoring, loud or noisy breathing during sleep, or witnessed sleep apnea. Polysomnography (PSG) data were available in 85% of children. Standardized neurocognitive tests were administered by a trained psychometrist unaware of the children's SDB status. Children with (n=61) and without SDB symptoms were compared using analysis of variance to adjust for demographic and respiratory health variables. Results Children with SDB symptoms scored significantly lower than those without SDB symptoms on tests of executive function (95.5 vs 99.9 on NEPSY Attention/Executive Core Domain, P=.02; 10.4 vs 11.2 on Wechsler Preschool and Primary Scale of Intelligence, Revised [WPPSI-R] Animal Pegs test, P=.03), memory (96.8 vs 103.0 on NEPSY Memory Domain, P=.02), and general intellectual ability (105.9 vs 111.7 on WPPSI-R Full Scale IQ, P=.02). There were no significant differences on a computerized continuous performance task. These findings persisted when children with PSG evidence of obstructive sleep apnea (OSA) were excluded from analysis. Conclusion Even in the absence of OSA, SDB symptoms are associated with poorer executive function and memory skills and lower general intelligence in 5-year-old children.
KW - ADHD
KW - AHI
KW - Apnea-Hypopnea Index
KW - Attention deficit-hyperactivity disorder
KW - CPRS
KW - CPT
KW - Conners' Parent Rating Scale, Long Form
KW - Continuous performance task
KW - FYFQ
KW - Five-year follow-up questionnaire
KW - ICPS
KW - Infant Care Practices Study
KW - MANOVA
UR - http://www.scopus.com/inward/record.url?scp=5144224115&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=5144224115&partnerID=8YFLogxK
U2 - 10.1016/j.jpeds.2004.05.039
DO - 10.1016/j.jpeds.2004.05.039
M3 - Article
C2 - 15480367
AN - SCOPUS:5144224115
VL - 145
SP - 458
EP - 464
JO - Journal of Pediatrics
JF - Journal of Pediatrics
SN - 0022-3476
IS - 4
ER -