Sleep Disruption in Atopic Dermatitis

Duri Yun, Lacey Lea Kruse*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Sleep disruption in the setting of AD is multifactorial. Pruritus and scratching are known contributors to sleep disturbance, but more complex and systemic factors also affect sleep. The complex interactions between cytokines, melatonin, circadian rhythms, and pruritus prime AD skin for exacerbations at night. This leads to significant sleep disturbance and poorer quality of life. AD patients with sleep disturbance may also suffer growth disturbances, behavioral issues, and neurocognitive disorders. Recognizing these significant comorbidities associated with AD and sleep disruption highlights the global burden of this disorder on patients and should be accounted for in clinical management.

Original languageEnglish (US)
Title of host publicationAllergy and Sleep
Subtitle of host publicationBasic Principles and Clinical Practice
PublisherSpringer International Publishing
Number of pages9
ISBN (Electronic)9783030147389
ISBN (Print)9783030147372
StatePublished - Jan 1 2019


  • Atopic dermatitis
  • Atopic dermatitis and growth disruption
  • Inflammatory skin disease
  • Pruritus and sleep
  • Sleep disruption and atopic dermatitis

ASJC Scopus subject areas

  • General Medicine
  • General Immunology and Microbiology


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