Sleep disturbance and ovarian stimulation outcomes in infertility and fertility preservation patients

Brianna M.W. Lyttle, Angela K. Lawson, Susan Klock, Kristin Smith, Ralph Kazer, Jennifer Hirshfeld-Cytron, Mary Ellen Pavone*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


OBJECTIVE: To assess sleep patterns and ovarian stimulation outcomes in infertile as compared to fertility preservation (FP) patients with a concurrent cancer diagnosis undergoing controlled ovarian hyperstimulation (COH). STUDY DESIGN: Prospective survey study done at a single academic medical center examining sleep disturbance, medical diagnoses, anti-Müllerian hormone (AMH), and COH stimulation results using CES-D scale in 50 infertile and 32 age-matched FP patients. RESULTS: Sleep disturbance was significantly higher at baseline in FP patients. Over time, sleep disturbance significantly increased in infertile patients (T1 MOS-SS SCORE= 16; T2 MOS-SS SCORE=20) but not in FP patients (T1 MOS-SS SCORE=32; T2 MOS-SS SCORE=36). Sleep disturbance did correlate with CES-D scores for both infertile and FP patients. How ever, no correlations were found between sleep disturbance and AMH, peak estradiol, total medication received, number of oocytes retrieved, and number of oocytes frozen. CONCLUSION: Sleep scores for infertile patients significantly increased, often reaching values equivalent to national levels cited for chronic illnesses. For both infertile and FP patients, sleep scores correlated with CES-D scores but did not correlate with ovarian stimulation outcomes.

Original languageEnglish (US)
Pages (from-to)292-298
Number of pages7
JournalJournal of Reproductive Medicine
Issue number3
StatePublished - 2018


  • Assisted reproduction techniques
  • Controlled ovarian hyperstimulation
  • Infertility
  • Insufficient sleep syndrome
  • Ovarian stimulation
  • Ovulation induction
  • Sleep disorders
  • Sleep disturbance
  • Sleep fragmentation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology


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