TY - JOUR
T1 - Sleep disturbance and ovarian stimulation outcomes in infertility and fertility preservation patients
AU - Lyttle, Brianna M.W.
AU - Lawson, Angela K.
AU - Klock, Susan
AU - Smith, Kristin
AU - Kazer, Ralph
AU - Hirshfeld-Cytron, Jennifer
AU - Pavone, Mary Ellen
N1 - Publisher Copyright:
© Journal of Reproductive Medicine®, Inc.
PY - 2018
Y1 - 2018
N2 - OBJECTIVE: To assess sleep patterns and ovarian stimulation outcomes in infertile as compared to fertility preservation (FP) patients with a concurrent cancer diagnosis undergoing controlled ovarian hyperstimulation (COH). STUDY DESIGN: Prospective survey study done at a single academic medical center examining sleep disturbance, medical diagnoses, anti-Müllerian hormone (AMH), and COH stimulation results using CES-D scale in 50 infertile and 32 age-matched FP patients. RESULTS: Sleep disturbance was significantly higher at baseline in FP patients. Over time, sleep disturbance significantly increased in infertile patients (T1 MOS-SS SCORE= 16; T2 MOS-SS SCORE=20) but not in FP patients (T1 MOS-SS SCORE=32; T2 MOS-SS SCORE=36). Sleep disturbance did correlate with CES-D scores for both infertile and FP patients. How ever, no correlations were found between sleep disturbance and AMH, peak estradiol, total medication received, number of oocytes retrieved, and number of oocytes frozen. CONCLUSION: Sleep scores for infertile patients significantly increased, often reaching values equivalent to national levels cited for chronic illnesses. For both infertile and FP patients, sleep scores correlated with CES-D scores but did not correlate with ovarian stimulation outcomes.
AB - OBJECTIVE: To assess sleep patterns and ovarian stimulation outcomes in infertile as compared to fertility preservation (FP) patients with a concurrent cancer diagnosis undergoing controlled ovarian hyperstimulation (COH). STUDY DESIGN: Prospective survey study done at a single academic medical center examining sleep disturbance, medical diagnoses, anti-Müllerian hormone (AMH), and COH stimulation results using CES-D scale in 50 infertile and 32 age-matched FP patients. RESULTS: Sleep disturbance was significantly higher at baseline in FP patients. Over time, sleep disturbance significantly increased in infertile patients (T1 MOS-SS SCORE= 16; T2 MOS-SS SCORE=20) but not in FP patients (T1 MOS-SS SCORE=32; T2 MOS-SS SCORE=36). Sleep disturbance did correlate with CES-D scores for both infertile and FP patients. How ever, no correlations were found between sleep disturbance and AMH, peak estradiol, total medication received, number of oocytes retrieved, and number of oocytes frozen. CONCLUSION: Sleep scores for infertile patients significantly increased, often reaching values equivalent to national levels cited for chronic illnesses. For both infertile and FP patients, sleep scores correlated with CES-D scores but did not correlate with ovarian stimulation outcomes.
KW - Assisted reproduction techniques
KW - Controlled ovarian hyperstimulation
KW - Infertility
KW - Insufficient sleep syndrome
KW - Ovarian stimulation
KW - Ovulation induction
KW - Sleep disorders
KW - Sleep disturbance
KW - Sleep fragmentation
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M3 - Article
AN - SCOPUS:85048050212
SN - 0024-7758
VL - 63
SP - 292
EP - 298
JO - Journal of Reproductive Medicine
JF - Journal of Reproductive Medicine
IS - 3
ER -