La fatiga se vincula con los trastornos del sueño en la esclerosis múltiple

Fatigue is the most disabling symptom of multiple sclerosis (MS). Two years ago, we published our findings demonstrating a relationship between fatigue in MS and sleep disruptions. The following article is a brief review of all the papers published since then on the subject and our future plans to further investigate this relationship. The handful papers published on the subject over the last 2 years have shown no daytime sleepiness in mild to moderate MS patients both subjectively and objectively. No papers were published on nocturnal sleep in MS. There was one paper looking at the hypothalamic- pituitary-adrenal (HPA) axis dysfunction in the pathogenesis of MS fatigue which may mean that the HPA axis dysfunction is a common pathway for both MS fatigue and sleep disorders. At our center, we are looking at the relationship of fatigue in MS and insomnia and also MS fatigue and obstructive sleep apnea syndrome.