Sleep, melatonin, and the menopausal transition: What are the links?

Shazia Jehan; Giardin Jean-Louis; Ferdinand Zizi; Evan Auguste; Seitikurippu R. Pandi-Perumal; Ravi Gupta; Hrayr Attarian; Samy I. McFarlane; Rüdiger Hardeland; Amnon Brzezinski

doi:10.5935/1984-0063.20170003

Sleep, melatonin, and the menopausal transition: What are the links?

Shazia Jehan, Giardin Jean-Louis, Ferdinand Zizi, Evan Auguste, Seitikurippu R. Pandi-Perumal, Ravi Gupta, Hrayr Attarian, Samy I. McFarlane, Rüdiger Hardeland, Amnon Brzezinski^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The pineal hormone Melatonin plays an important role in the regulation of the circadian sleep/ wake cycle, mood, and perhaps immune functions, carcinogensis and reproduction. The human circadian rhythm of melatonin release from the pineal gland is tightly synchronized with the habitual hours of sleep. Peri-And postmenopausal women often complain of difficulties initiating and/or maintaining sleep, with frequent nocturnal and early morning awakenings. In this review we discuss the pathophysiology of melatonin function as it relates to sleep disorders in menopausal women, highlighting the potential use of exogenous melatonin during the menopausal transition and beyond.

Original language	English (US)
Pages (from-to)	11-18
Number of pages	8
Journal	Sleep Science
Volume	10
Issue number	1
DOIs	https://doi.org/10.5935/1984-0063.20170003
State	Published - 2017

Keywords

Aging
Circadian rhythm
Gender
Hormones
Melatonin
Menopause
Sleep

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Behavioral Neuroscience
Medicine (miscellaneous)

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10.5935/1984-0063.20170003

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title = "Sleep, melatonin, and the menopausal transition: What are the links?",

abstract = "The pineal hormone Melatonin plays an important role in the regulation of the circadian sleep/ wake cycle, mood, and perhaps immune functions, carcinogensis and reproduction. The human circadian rhythm of melatonin release from the pineal gland is tightly synchronized with the habitual hours of sleep. Peri-And postmenopausal women often complain of difficulties initiating and/or maintaining sleep, with frequent nocturnal and early morning awakenings. In this review we discuss the pathophysiology of melatonin function as it relates to sleep disorders in menopausal women, highlighting the potential use of exogenous melatonin during the menopausal transition and beyond.",

keywords = "Aging, Circadian rhythm, Gender, Hormones, Melatonin, Menopause, Sleep",

author = "Shazia Jehan and Giardin Jean-Louis and Ferdinand Zizi and Evan Auguste and Pandi-Perumal, {Seitikurippu R.} and Ravi Gupta and Hrayr Attarian and McFarlane, {Samy I.} and R{\"u}diger Hardeland and Amnon Brzezinski",

note = "Funding Information: This work is supported by the following funding agencies: R25-HL105444 and R25-HL116378 (NHLBI); R01-MD007716 (NIMHD) to GJL. However, the funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.",

year = "2017",

doi = "10.5935/1984-0063.20170003",

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AU - Zizi, Ferdinand

AU - Auguste, Evan

AU - Pandi-Perumal, Seitikurippu R.

AU - Gupta, Ravi

AU - Attarian, Hrayr

AU - McFarlane, Samy I.

AU - Hardeland, Rüdiger

AU - Brzezinski, Amnon

N1 - Funding Information: This work is supported by the following funding agencies: R25-HL105444 and R25-HL116378 (NHLBI); R01-MD007716 (NIMHD) to GJL. However, the funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

PY - 2017

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N2 - The pineal hormone Melatonin plays an important role in the regulation of the circadian sleep/ wake cycle, mood, and perhaps immune functions, carcinogensis and reproduction. The human circadian rhythm of melatonin release from the pineal gland is tightly synchronized with the habitual hours of sleep. Peri-And postmenopausal women often complain of difficulties initiating and/or maintaining sleep, with frequent nocturnal and early morning awakenings. In this review we discuss the pathophysiology of melatonin function as it relates to sleep disorders in menopausal women, highlighting the potential use of exogenous melatonin during the menopausal transition and beyond.

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KW - Aging

KW - Circadian rhythm

KW - Gender

KW - Hormones

KW - Melatonin

KW - Menopause

KW - Sleep

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Sleep, melatonin, and the menopausal transition: What are the links?

Abstract

Keywords

ASJC Scopus subject areas

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