Sleep-related hypermotor epilepsy in a patient with mucopolysaccharidosis type III

Anna A. Abramova*, Hrayr P. Attarian, Snezhana M. Dolgova, Alexandra I. Belyakova-Bodina, Elena V. Iakovenko, Amayak G. Broutian

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Both non-epileptic sleep disturbances and epilepsy are common in patients with mucopolysaccharidoses (MPS), so diagnosis of sleep-related hypermotor epilepsy in these patients is a tackling issue. We present a case of an adult patient with MPS IIIB (Sanfilippo syndrome), who presented with numerous nocturnal events of sudden awakening and hypermotor behavior, which had been previously regarded as parasomnias. Overnight video-EEG captured numerous stereotypical seizures with ictal pattern in the frontal regions, which led the diagnosis of SHE. The patient was started with carbamazepine, which resulted in a substantial reduction in the number of seizures. Our report provides further support for use of overnight video-EEG in the differential diagnosis of sleeprelated disorders in MPS, yet true incidence of SHE in MPS patients remains unknown.

Original languageEnglish (US)
Pages (from-to)97-100
Number of pages4
JournalSleep Science
Volume14
DOIs
StatePublished - 2021

Keywords

  • Hypermotor Seizures
  • Mucopolysaccharidosis
  • Parasomnias
  • Sanfilippo Syndrome
  • Sleep-related Hypermotor Epilepsy

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Medicine (miscellaneous)
  • Behavioral Neuroscience

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