Sleep timing and circadian phase in delayed sleep phase syndrome

Anne Marie Chang*, Kathryn Jean Reid, Ramadevi Gourineni, Phyllis C Zee

*Corresponding author for this work

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Delayed sleep phase syndrome (DSPS) is a circadian rhythm sleep disorder in which the timing of the sleep episode occurs later than desired and is associated with difficulty falling asleep, problems awakening on time (e.g., to meet work or school obligations), and daytime sleepiness. The phase relationship between the timing of sleep and endogenous circadian rhythms is critical to the initiation and maintenance of sleep, and significant alteration leads to impairment of sleep quality and duration. The aim of this retrospective study was to determine the phase relationship between sleep-wake times and physiological markers of circadian timing in clinic patients with DSPS. Objective and subjective measures of sleep timing and circadian phase markers (core body temperature and melatonin) were measured in patients with DSPS and compared with age-matched controls. As expected, significant delays in the timing of the major sleep episode and circadian phase of body temperature and melatonin rhythms were seen in the DSPS group when allowed to sleep at their own habitual schedules, but the phase relationship between sleep-wake times and circadian phase was similar between the 2 groups. These results suggest that the symptoms of insomnia and excessive daytime sleepiness in DSPS patients living under entrained real-life conditions cannot be explained by an alteration in the phase relationship between sleep-wake patterns and other physiological circadian rhythms.

Original languageEnglish (US)
Pages (from-to)313-321
Number of pages9
JournalJournal of biological rhythms
Volume24
Issue number4
DOIs
StatePublished - Aug 1 2009

Fingerprint

Circadian Rhythm Sleep Disorders
Sleep
Melatonin
Circadian Rhythm
Body Temperature
Sleep Initiation and Maintenance Disorders
Appointments and Schedules
Retrospective Studies

Keywords

  • Circadian phase
  • Circadian phase angle
  • Circadian rhythm sleep disorder
  • DSPS

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

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abstract = "Delayed sleep phase syndrome (DSPS) is a circadian rhythm sleep disorder in which the timing of the sleep episode occurs later than desired and is associated with difficulty falling asleep, problems awakening on time (e.g., to meet work or school obligations), and daytime sleepiness. The phase relationship between the timing of sleep and endogenous circadian rhythms is critical to the initiation and maintenance of sleep, and significant alteration leads to impairment of sleep quality and duration. The aim of this retrospective study was to determine the phase relationship between sleep-wake times and physiological markers of circadian timing in clinic patients with DSPS. Objective and subjective measures of sleep timing and circadian phase markers (core body temperature and melatonin) were measured in patients with DSPS and compared with age-matched controls. As expected, significant delays in the timing of the major sleep episode and circadian phase of body temperature and melatonin rhythms were seen in the DSPS group when allowed to sleep at their own habitual schedules, but the phase relationship between sleep-wake times and circadian phase was similar between the 2 groups. These results suggest that the symptoms of insomnia and excessive daytime sleepiness in DSPS patients living under entrained real-life conditions cannot be explained by an alteration in the phase relationship between sleep-wake patterns and other physiological circadian rhythms.",
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Sleep timing and circadian phase in delayed sleep phase syndrome. / Chang, Anne Marie; Reid, Kathryn Jean; Gourineni, Ramadevi; Zee, Phyllis C.

In: Journal of biological rhythms, Vol. 24, No. 4, 01.08.2009, p. 313-321.

Research output: Contribution to journalArticle

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