Sleep Timing, Stability, and BP in the Sueño Ancillary Study of the Hispanic Community Health Study/Study of Latinos

Sabra M. Abbott; Jia Weng; Kathryn J. Reid; Martha L. Daviglus; Linda C. Gallo; Jose S. Loredo; Sharmilee M. Nyenhuis; Alberto R. Ramos; Neomi A. Shah; Daniela Sotres-Alvarez; Sanjay R. Patel; Phyllis C. Zee

doi:10.1016/j.chest.2018.09.018

Sleep Timing, Stability, and BP in the Sueño Ancillary Study of the Hispanic Community Health Study/Study of Latinos

Sabra M. Abbott^*, Jia Weng, Kathryn J. Reid, Martha L. Daviglus, Linda C. Gallo, Jose S. Loredo, Sharmilee M. Nyenhuis, Alberto R. Ramos, Neomi A. Shah, Daniela Sotres-Alvarez, Sanjay R. Patel, Phyllis C. Zee

^*Corresponding author for this work

Neurology

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Abstract

Background: Timing and stability of the sleep-wake cycle are potential modifiable risk factors for cardiometabolic disease. The aim of this study was to evaluate the relationship between objective measures of sleep-wake timing and stability with cardiometabolic disease risk. Methods: In this multicenter, cross-sectional, population-based study, actigraphy data were obtained from the 2,156 adults, aged 18 to 64 years, recruited from the Sueño ancillary study of the Hispanic Community Health Study/Study of Latinos (2010-2013). These data were correlated with measures of cardiometabolic disease risk, including systolic and diastolic BPs, homeostatic assessment of insulin resistance, glycosylated hemoglobin, BMI, and hypertension and diabetes status. Results: Each 10% decrease in interdaily stability was associated with a 3.0% absolute increase in the prevalence of hypertension (95% CI, 0.6-5.3; P <.05), an increase in systolic BP by 0.78 mm Hg (95% CI, 0.12-1.45; P <.05) and an increase in diastolic BP by 0.80 mm Hg (95% CI, 0.28-1.32; P <.05). In addition, delaying the midpoint of sleep by 1 h was associated with an increase in systolic BP by 0.73 mm Hg (95% CI, 0.30-1.16; P <.01) and diastolic BP by 0.53 mm Hg (95% CI, 0.17-0.90; P <.01). These associations were not significant after adjusting for shift work status. No association was found between interdaily stability or sleep timing and diabetes, BMI, or insulin resistance. Conclusions: These results suggest that beyond sleep duration, the timing and regularity of sleep-wake schedules are related to hypertension prevalence and BP.

Original language	English (US)
Pages (from-to)	60-68
Number of pages	9
Journal	CHEST
Volume	155
Issue number	1
DOIs	https://doi.org/10.1016/j.chest.2018.09.018
State	Published - Jan 2019

Funding

FUNDING/SUPPORT: This work was supported by the National Heart, Lung, and Blood Institute (NHLBI) [Grants HL098297 and HL127307]. The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) was conducted as a collaborative study supported by contracts from the NHLBI to the University of North Carolina [N01-HC65233], the University of Miami [N01-HC65234], Albert Einstein College of Medicine [N01-HC65235], Northwestern University [N01-HC65236], and San Diego State University [N01-HC65237]. The following institutes/centers/offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: the National Center on Minority Health and Health Disparities, the National Institute of Deafness and Other Communications Disorders, the National Institute of Dental and Craniofacial Research, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurological Disorders and Stroke, and the Office of Dietary Supplements. FUNDING/SUPPORT: This work was supported by the National Heart, Lung, and Blood Institute (NHLBI) [Grants HL098297 and HL127307 ]. The Hispanic Community Health Study/Study of Latinos (HCHS/SOL) was conducted as a collaborative study supported by contracts from the NHLBI to the University of North Carolina [ N01-HC65233 ], the University of Miami [ N01-HC65234 ], Albert Einstein College of Medicine [ N01-HC65235 ], Northwestern University [ N01-HC65236 ], and San Diego State University [ N01-HC65237 ]. The following institutes/centers/offices contribute to the HCHS/SOL through a transfer of funds to the NHLBI: the National Center on Minority Health and Health Disparities, the National Institute of Deafness and Other Communications Disorders, the National Institute of Dental and Craniofacial Research, the National Institute of Diabetes and Digestive and Kidney Diseases, the National Institute of Neurological Disorders and Stroke, and the Office of Dietary Supplements.

Keywords

cardiovascular diseases
circadian rhythm
hypertension
sleep

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine
Cardiology and Cardiovascular Medicine
Pulmonary and Respiratory Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.chest.2018.09.018

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@article{f7886eeda7a24bf28273dd6d67768a8f,

title = "Sleep Timing, Stability, and BP in the Sue{\~n}o Ancillary Study of the Hispanic Community Health Study/Study of Latinos",

abstract = "Background: Timing and stability of the sleep-wake cycle are potential modifiable risk factors for cardiometabolic disease. The aim of this study was to evaluate the relationship between objective measures of sleep-wake timing and stability with cardiometabolic disease risk. Methods: In this multicenter, cross-sectional, population-based study, actigraphy data were obtained from the 2,156 adults, aged 18 to 64 years, recruited from the Sue{\~n}o ancillary study of the Hispanic Community Health Study/Study of Latinos (2010-2013). These data were correlated with measures of cardiometabolic disease risk, including systolic and diastolic BPs, homeostatic assessment of insulin resistance, glycosylated hemoglobin, BMI, and hypertension and diabetes status. Results: Each 10% decrease in interdaily stability was associated with a 3.0% absolute increase in the prevalence of hypertension (95% CI, 0.6-5.3; P <.05), an increase in systolic BP by 0.78 mm Hg (95% CI, 0.12-1.45; P <.05) and an increase in diastolic BP by 0.80 mm Hg (95% CI, 0.28-1.32; P <.05). In addition, delaying the midpoint of sleep by 1 h was associated with an increase in systolic BP by 0.73 mm Hg (95% CI, 0.30-1.16; P <.01) and diastolic BP by 0.53 mm Hg (95% CI, 0.17-0.90; P <.01). These associations were not significant after adjusting for shift work status. No association was found between interdaily stability or sleep timing and diabetes, BMI, or insulin resistance. Conclusions: These results suggest that beyond sleep duration, the timing and regularity of sleep-wake schedules are related to hypertension prevalence and BP.",

keywords = "cardiovascular diseases, circadian rhythm, hypertension, sleep",

author = "Abbott, {Sabra M.} and Jia Weng and Reid, {Kathryn J.} and Daviglus, {Martha L.} and Gallo, {Linda C.} and Loredo, {Jose S.} and Nyenhuis, {Sharmilee M.} and Ramos, {Alberto R.} and Shah, {Neomi A.} and Daniela Sotres-Alvarez and Patel, {Sanjay R.} and Zee, {Phyllis C.}",

note = "Publisher Copyright: {\textcopyright} 2018 American College of Chest Physicians",

year = "2019",

month = jan,

doi = "10.1016/j.chest.2018.09.018",

language = "English (US)",

volume = "155",

pages = "60--68",

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T1 - Sleep Timing, Stability, and BP in the Sueño Ancillary Study of the Hispanic Community Health Study/Study of Latinos

AU - Abbott, Sabra M.

AU - Weng, Jia

AU - Reid, Kathryn J.

AU - Daviglus, Martha L.

AU - Gallo, Linda C.

AU - Loredo, Jose S.

AU - Nyenhuis, Sharmilee M.

AU - Ramos, Alberto R.

AU - Shah, Neomi A.

AU - Sotres-Alvarez, Daniela

AU - Patel, Sanjay R.

AU - Zee, Phyllis C.

PY - 2019/1

Y1 - 2019/1

N2 - Background: Timing and stability of the sleep-wake cycle are potential modifiable risk factors for cardiometabolic disease. The aim of this study was to evaluate the relationship between objective measures of sleep-wake timing and stability with cardiometabolic disease risk. Methods: In this multicenter, cross-sectional, population-based study, actigraphy data were obtained from the 2,156 adults, aged 18 to 64 years, recruited from the Sueño ancillary study of the Hispanic Community Health Study/Study of Latinos (2010-2013). These data were correlated with measures of cardiometabolic disease risk, including systolic and diastolic BPs, homeostatic assessment of insulin resistance, glycosylated hemoglobin, BMI, and hypertension and diabetes status. Results: Each 10% decrease in interdaily stability was associated with a 3.0% absolute increase in the prevalence of hypertension (95% CI, 0.6-5.3; P <.05), an increase in systolic BP by 0.78 mm Hg (95% CI, 0.12-1.45; P <.05) and an increase in diastolic BP by 0.80 mm Hg (95% CI, 0.28-1.32; P <.05). In addition, delaying the midpoint of sleep by 1 h was associated with an increase in systolic BP by 0.73 mm Hg (95% CI, 0.30-1.16; P <.01) and diastolic BP by 0.53 mm Hg (95% CI, 0.17-0.90; P <.01). These associations were not significant after adjusting for shift work status. No association was found between interdaily stability or sleep timing and diabetes, BMI, or insulin resistance. Conclusions: These results suggest that beyond sleep duration, the timing and regularity of sleep-wake schedules are related to hypertension prevalence and BP.

AB - Background: Timing and stability of the sleep-wake cycle are potential modifiable risk factors for cardiometabolic disease. The aim of this study was to evaluate the relationship between objective measures of sleep-wake timing and stability with cardiometabolic disease risk. Methods: In this multicenter, cross-sectional, population-based study, actigraphy data were obtained from the 2,156 adults, aged 18 to 64 years, recruited from the Sueño ancillary study of the Hispanic Community Health Study/Study of Latinos (2010-2013). These data were correlated with measures of cardiometabolic disease risk, including systolic and diastolic BPs, homeostatic assessment of insulin resistance, glycosylated hemoglobin, BMI, and hypertension and diabetes status. Results: Each 10% decrease in interdaily stability was associated with a 3.0% absolute increase in the prevalence of hypertension (95% CI, 0.6-5.3; P <.05), an increase in systolic BP by 0.78 mm Hg (95% CI, 0.12-1.45; P <.05) and an increase in diastolic BP by 0.80 mm Hg (95% CI, 0.28-1.32; P <.05). In addition, delaying the midpoint of sleep by 1 h was associated with an increase in systolic BP by 0.73 mm Hg (95% CI, 0.30-1.16; P <.01) and diastolic BP by 0.53 mm Hg (95% CI, 0.17-0.90; P <.01). These associations were not significant after adjusting for shift work status. No association was found between interdaily stability or sleep timing and diabetes, BMI, or insulin resistance. Conclusions: These results suggest that beyond sleep duration, the timing and regularity of sleep-wake schedules are related to hypertension prevalence and BP.

KW - cardiovascular diseases

KW - circadian rhythm

KW - hypertension

KW - sleep

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Sleep Timing, Stability, and BP in the Sueño Ancillary Study of the Hispanic Community Health Study/Study of Latinos

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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