Sleep Timing, Stability, and BP in the Sueño Ancillary Study of the Hispanic Community Health Study/Study of Latinos

Sabra M. Abbott*, Jia Weng, Kathryn J. Reid, Martha L. Daviglus, Linda C. Gallo, Jose S. Loredo, Sharmilee M. Nyenhuis, Alberto R. Ramos, Neomi A. Shah, Daniela Sotres-Alvarez, Sanjay R. Patel, Phyllis C. Zee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


Background: Timing and stability of the sleep-wake cycle are potential modifiable risk factors for cardiometabolic disease. The aim of this study was to evaluate the relationship between objective measures of sleep-wake timing and stability with cardiometabolic disease risk. Methods: In this multicenter, cross-sectional, population-based study, actigraphy data were obtained from the 2,156 adults, aged 18 to 64 years, recruited from the Sueño ancillary study of the Hispanic Community Health Study/Study of Latinos (2010-2013). These data were correlated with measures of cardiometabolic disease risk, including systolic and diastolic BPs, homeostatic assessment of insulin resistance, glycosylated hemoglobin, BMI, and hypertension and diabetes status. Results: Each 10% decrease in interdaily stability was associated with a 3.0% absolute increase in the prevalence of hypertension (95% CI, 0.6-5.3; P <.05), an increase in systolic BP by 0.78 mm Hg (95% CI, 0.12-1.45; P <.05) and an increase in diastolic BP by 0.80 mm Hg (95% CI, 0.28-1.32; P <.05). In addition, delaying the midpoint of sleep by 1 h was associated with an increase in systolic BP by 0.73 mm Hg (95% CI, 0.30-1.16; P <.01) and diastolic BP by 0.53 mm Hg (95% CI, 0.17-0.90; P <.01). These associations were not significant after adjusting for shift work status. No association was found between interdaily stability or sleep timing and diabetes, BMI, or insulin resistance. Conclusions: These results suggest that beyond sleep duration, the timing and regularity of sleep-wake schedules are related to hypertension prevalence and BP.

Original languageEnglish (US)
Pages (from-to)60-68
Number of pages9
Issue number1
StatePublished - Jan 2019


  • cardiovascular diseases
  • circadian rhythm
  • hypertension
  • sleep

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine


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