Slit and robo: Expression patterns in lung development

Mark A. Anselmo, Sussie Dalvin, Parthak Prodhan, Katsumi Komatsuzaki, Jeremy T. Aidlen, Jay J. Schnitzer, Jane Y. Wu, T. Bernard Kinane*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

First described as an axonal guidance cue through its repulsive effect on neurons expressing its receptor Roundabout (Robo), the Slit ligand has effects on cell migration, axon branching and elongation. Indirect evidence implicates Slit and Robo in lung development. We now demonstrate that Slit-2 and Slit-3 are developmentally regulated in embryonic murine lung. Immunohistochemistry demonstrates Slit-2 and Slit-3 expression by the pulmonary mesenchyme and airway epithelium. Robo-1 and Robo-2 are also expressed by the developing mesenchyme and airway epithelium. As lung development progresses, Robo-1 and Robo-2 expression localizes to only the airway epithelium. We conclude Slit/Robo are expressed in temporo-spatially adjacent domains suggesting in teractive roles in pulmonary bronchiolar development.

Original languageEnglish (US)
Pages (from-to)13-19
Number of pages7
JournalGene Expression Patterns
Volume3
Issue number1
DOIs
StatePublished - Mar 2003

Keywords

  • Branching morphogenesis
  • Lung development
  • Robo
  • Slit

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Developmental Biology

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