Slit proteins: Molecular guidance cues for cells ranging from neurons to leukocytes

Kit Wong*, Hwan Tae Park, Jane Y. Wu, Yi Rao

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

170 Scopus citations

Abstract

Recent studies of molecular guidance cues including the Slit family of secreted proteins have provided new insights into the mechanisms of cell migration. Initially discovered in the nervous system, Slit functions through its receptor, Roundabout, and an intracellular signal transduction pathway that includes the Abelson kinase, the Enabled protein, GTPase activating proteins and the Rho family of small GTPases. Interestingly, Slit also appears to use Roundabout to control leukocyte chemotaxis, which occurs in contexts different from neuronal migration, suggesting a fundamental conservation of mechanisms guiding the migration of distinct types of somatic cells.

Original languageEnglish (US)
Pages (from-to)583-591
Number of pages9
JournalCurrent Opinion in Genetics and Development
Volume12
Issue number5
DOIs
StatePublished - Oct 1 2002

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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