TY - JOUR
T1 - Slit proteins
T2 - Molecular guidance cues for cells ranging from neurons to leukocytes
AU - Wong, Kit
AU - Park, Hwan Tae
AU - Wu, Jane Y.
AU - Rao, Yi
PY - 2002/10/1
Y1 - 2002/10/1
N2 - Recent studies of molecular guidance cues including the Slit family of secreted proteins have provided new insights into the mechanisms of cell migration. Initially discovered in the nervous system, Slit functions through its receptor, Roundabout, and an intracellular signal transduction pathway that includes the Abelson kinase, the Enabled protein, GTPase activating proteins and the Rho family of small GTPases. Interestingly, Slit also appears to use Roundabout to control leukocyte chemotaxis, which occurs in contexts different from neuronal migration, suggesting a fundamental conservation of mechanisms guiding the migration of distinct types of somatic cells.
AB - Recent studies of molecular guidance cues including the Slit family of secreted proteins have provided new insights into the mechanisms of cell migration. Initially discovered in the nervous system, Slit functions through its receptor, Roundabout, and an intracellular signal transduction pathway that includes the Abelson kinase, the Enabled protein, GTPase activating proteins and the Rho family of small GTPases. Interestingly, Slit also appears to use Roundabout to control leukocyte chemotaxis, which occurs in contexts different from neuronal migration, suggesting a fundamental conservation of mechanisms guiding the migration of distinct types of somatic cells.
UR - http://www.scopus.com/inward/record.url?scp=0036777901&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036777901&partnerID=8YFLogxK
U2 - 10.1016/S0959-437X(02)00343-X
DO - 10.1016/S0959-437X(02)00343-X
M3 - Review article
C2 - 12200164
AN - SCOPUS:0036777901
SN - 0959-437X
VL - 12
SP - 583
EP - 591
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 5
ER -