Slutamine-dependent carbamyl phosphate synthetase in placenta and fetal structures of the rat

George E. Shambaugh*, Boyd E. Metzger, Norbert Freinkel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Glutamine-dependent carbamyl phosphate synthetase activity has been demonstrated in fetal liver, gut, carcass, and brain and in the placenta of the 19-day pregnant rat. The widespread distribution of this enzyme within the conceptus indicates that even the first step in the de novo biosynthesis of pyrimidines can occur in situ. It also suggests that formation of nucleic acids by the conceptus during fasting may be supported by products of maternal protein catabolism.

Original languageEnglish (US)
Pages (from-to)155-158
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume42
Issue number2
DOIs
StatePublished - Jan 22 1971

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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