Glutamine-dependent carbamyl phosphate synthetase activity has been demonstrated in fetal liver, gut, carcass, and brain and in the placenta of the 19-day pregnant rat. The widespread distribution of this enzyme within the conceptus indicates that even the first step in the de novo biosynthesis of pyrimidines can occur in situ. It also suggests that formation of nucleic acids by the conceptus during fasting may be supported by products of maternal protein catabolism.
|Original language||English (US)|
|Number of pages||4|
|Journal||Biochemical and Biophysical Research Communications|
|State||Published - Jan 22 1971|
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology