TY - JOUR
T1 - Slutamine-dependent carbamyl phosphate synthetase in placenta and fetal structures of the rat
AU - Shambaugh, George E.
AU - Metzger, Boyd E.
AU - Freinkel, Norbert
N1 - Funding Information:
This work was supported in part by Training Grant AM-05071 and Research Grant AM-10699, National Institute of Arthritis and Metabolic Diseases, U.S.P.H.S., Bethesda, Maryland. The technical assistance of Mrs. Esther Rasson is gratefully acknowledged.
PY - 1971/1/22
Y1 - 1971/1/22
N2 - Glutamine-dependent carbamyl phosphate synthetase activity has been demonstrated in fetal liver, gut, carcass, and brain and in the placenta of the 19-day pregnant rat. The widespread distribution of this enzyme within the conceptus indicates that even the first step in the de novo biosynthesis of pyrimidines can occur in situ. It also suggests that formation of nucleic acids by the conceptus during fasting may be supported by products of maternal protein catabolism.
AB - Glutamine-dependent carbamyl phosphate synthetase activity has been demonstrated in fetal liver, gut, carcass, and brain and in the placenta of the 19-day pregnant rat. The widespread distribution of this enzyme within the conceptus indicates that even the first step in the de novo biosynthesis of pyrimidines can occur in situ. It also suggests that formation of nucleic acids by the conceptus during fasting may be supported by products of maternal protein catabolism.
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U2 - 10.1016/0006-291X(71)90081-7
DO - 10.1016/0006-291X(71)90081-7
M3 - Article
C2 - 5545507
AN - SCOPUS:0015235741
VL - 42
SP - 155
EP - 158
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 2
ER -