Small bowel transplantation

Juan P. Rocca*, Jonathan P. Fryer

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Parenteral nutrition (PN) is the primary therapeutic option for intestinal failure (IF) patients and intestinal transplant (ITx) has a potential life saving role for those patients with PN failure. Most IF patients are not referred for ITx until irreversible PN - associated liver disease (PNALD) has developed and they need a liver transplant also, leading to inferior outcomes compared to patients referred earlier for isolated ITx. Intestinal rehabilitation attempts to optimize the function of the intestine with the goal of subsequently weaning PN completely or partially while expediting the identifi cation of cases not weanable from PN and at highest risk of PN failure, where early ITx needs to be considered. Collaboration with intestinal rehabilitation centers should be initiated for IF patients if PN requirements are anticipated to be 50% or more at 3 months from the initiation of therapy. Outcomes with intestinal transplantation are steadily improving, with 1 - year patient survival rates for isolated ITx being similar to liver transplant.

Original languageEnglish (US)
Title of host publicationPractical Gastroenterology and Hepatology
Subtitle of host publicationSmall and Large Intestine and Pancreas
Number of pages5
ISBN (Electronic)9781444328417
ISBN (Print)9781405182744
StatePublished - Aug 31 2010

ASJC Scopus subject areas

  • Medicine(all)


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