Small cell lung cancer: Clinical Practice Guidelines in Oncology™

Bruce E. Johnson*, Jeffrey Crawford, Robert J. Downey, David S. Ettinger, Frank Fossella, John C. Grecula, Thierry Jahan, Gregory P. Kalemkerian, Anne Kessinger, Marianna Koczywas, Corey J. Langer, Renato Martins, Maryanne Hoffman Marymont, Harvey B. Niell, Nithya Ramnath, Francisco Robert, Charles C. Williams

*Corresponding author for this work

Research output: Contribution to journalReview article

37 Scopus citations

Abstract

In 2005, approximately 26,000 new cases of small cell lung cancer were diagnosed in the United States. When compared with non-small cell lung cancer, SCLC generally has a more rapid doubling time, a higher growth fraction, and earlier development of widespread metastases. SCLC is highly sensitive to initial chemotherapy and radiotherapy. Treatment with chemotherapy plus chest radiotherapy can be curative for some patients with limited-stage SCLC, whereas most patients with extensive-stage disease who undergo chemotherapy alone experience palliated symptoms and prolonged survival. The updated 2006 NCCN guidelines include new principles of surgical resection as well as chemotherapy and radiation dosage changes.

Original languageEnglish (US)
Pages (from-to)602-622
Number of pages21
JournalJNCCN Journal of the National Comprehensive Cancer Network
Volume4
Issue number6
StatePublished - Jul 1 2006

Keywords

  • Carcinoma
  • Chemotherapy
  • Mediastinum
  • Metastases
  • NCCN Clinical Practice Guidelines
  • Pulmonary carcinogenesis
  • Radiotherapy
  • Small cell
  • Surgical resection
  • Targeted therapy

ASJC Scopus subject areas

  • Oncology

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  • Cite this

    Johnson, B. E., Crawford, J., Downey, R. J., Ettinger, D. S., Fossella, F., Grecula, J. C., Jahan, T., Kalemkerian, G. P., Kessinger, A., Koczywas, M., Langer, C. J., Martins, R., Marymont, M. H., Niell, H. B., Ramnath, N., Robert, F., & Williams, C. C. (2006). Small cell lung cancer: Clinical Practice Guidelines in Oncology™. JNCCN Journal of the National Comprehensive Cancer Network, 4(6), 602-622.