Small P values may not yield robust findings: an example using REST-meta-PD

Xi Ze Jia; Na Zhao; Hao Ming Dong; Jia Wei Sun; Marek Barton; Roxana Burciu; Nicolas Carrière; Antonio Cerasa; Bo Yu Chen; Jun Chen; Stephen Coombes; Luc Defebvre; Christine Delmaire; Kathy Dujardin; Fabrizio Esposito; Guo Guang Fan; Federica Di Nardo; Yi Xuan Feng; Brett W. Fling; Saurabh Garg; Moran Gilat; Martin Gorges; Shu Leong Ho; Fay B. Horak; Xiao Hu; Xiao Fei Hu; Biao Huang; Pei Yu Huang; Ze Juan Jia; Christina Jones; Jan Kassubek; Lenka Krajcovicova; Ajay Kurani; Jing Li; Qing Li; Ai Ping Liu; Bo Liu; Hu Liu; Wei Guo Liu; Renaud Lopes; Yu Ting Lou; Wei Luo; Tara Madhyastha; Ni Ni Mao; Grainne McAlonan; Martin J. McKeown; Shirley Pang; Andrea Quattrone; Irena Rektorova; Alessia Sarica; Hui Fang Shang; James M. Shine; Priyank Shukla; Tomas Slavicek; Xiao Peng Song; Gioacchino Tedeschi; Alessandro Tessitore; David Vaillancourt; Jian Wang; Jue Wang; Z. Jane Wang; Lu Qing Wei; Xia Wu; Xiao Jun Xu; Lei Yan; Jing Yang; Wan Qun Yang; Nai Lin Yao; De Long Zhang; Jiu Quan Zhang; Min Ming Zhang; Yan Ling Zhang; Cai Hong Zhou; Chao Gan Yan; Xi Nian Zuo; Mark Hallett; Tao Wu; Yu Feng Zang

doi:10.1016/j.scib.2021.06.007

Small P values may not yield robust findings: an example using REST-meta-PD

Xi Ze Jia, Na Zhao, Hao Ming Dong, Jia Wei Sun, Marek Barton, Roxana Burciu, Nicolas Carrière, Antonio Cerasa, Bo Yu Chen, Jun Chen, Stephen Coombes, Luc Defebvre, Christine Delmaire, Kathy Dujardin, Fabrizio Esposito, Guo Guang Fan, Federica Di Nardo, Yi Xuan Feng, Brett W. Fling, Saurabh GargMoran Gilat, Martin Gorges, Shu Leong Ho, Fay B. Horak, Xiao Hu, Xiao Fei Hu, Biao Huang, Pei Yu Huang, Ze Juan Jia, Christina Jones, Jan Kassubek, Lenka Krajcovicova, Ajay Kurani, Jing Li, Qing Li, Ai Ping Liu, Bo Liu, Hu Liu, Wei Guo Liu, Renaud Lopes, Yu Ting Lou, Wei Luo, Tara Madhyastha, Ni Ni Mao, Grainne McAlonan, Martin J. McKeown, Shirley Pang, Andrea Quattrone, Irena Rektorova, Alessia Sarica, Hui Fang Shang, James M. Shine, Priyank Shukla, Tomas Slavicek, Xiao Peng Song, Gioacchino Tedeschi, Alessandro Tessitore, David Vaillancourt, Jian Wang, Jue Wang, Z. Jane Wang, Lu Qing Wei, Xia Wu, Xiao Jun Xu, Lei Yan, Jing Yang, Wan Qun Yang, Nai Lin Yao, De Long Zhang, Jiu Quan Zhang, Min Ming Zhang, Yan Ling Zhang, Cai Hong Zhou, Chao Gan Yan, Xi Nian Zuo^*, Mark Hallett, Tao Wu, Yu Feng Zang

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › peer-review

24 Scopus citations

Original language	English (US)
Pages (from-to)	2148-2152
Number of pages	5
Journal	Science Bulletin
Volume	66
Issue number	21
DOIs	https://doi.org/10.1016/j.scib.2021.06.007
State	Published - Nov 15 2021

Funding

We are grateful to all investigators who helped in data collection. This work was supported by the National Natural Science Foundation of China , China ( 81520108016 , 81661148045 , and 31471084 to Yu-Feng Zang; 81671774 and 81630031 to Chao-Gan Yan; 81571228 to Tao Wu; 61571047 to Xia Wu; 81701664 to Jian Wang, 81471654 to Biao Huang; 81701671 to Wei-Guo Liu; 82001898 to Xi-Ze Jia; 81771820 , 81371519 and 81571654 to Wei Luo), Henry G Leong Endowed Professorship in Neurology to Shu-Leong Ho and Shirley YY Pang, BRC for Mental Health at South London and Maudsley NHS Foundation Trust and by the Sackler Institute to Grainne McAlonan, NIH ( 2R01AG006457 to Fay B. Horak; 1RC4NS073008-01 and P50NS062684 to Tara Madhyastha), NINDS Intramural Research Program to Mark Hallett, Start-up Funds for Leading Talents at Beijing Normal University and National Basic Science Data Center “Chinese Data-sharing Warehouse for In-vivo Imaging Brain” (NBSDC-DB-15) to Xi-Nian Zuo, and Grant NU20-04-00294 of the Agency for Health Research, Czech Republic to Lenka Krajcovicova and Irena Rektorova. We thank Dr. Chao Jiang from Capital Normal University for his assistance on figure-making. We are grateful to all investigators who helped in data collection. This work was supported by the National Natural Science Foundation of China (81520108016, 81661148045, and 31471084 to Yu-Feng Zang; 81671774 and 81630031 to Chao-Gan Yan; 81571228 to Tao Wu; 61571047 to Xia Wu; 81701664 to Jian Wang, 81471654 to Biao Huang; 81701671 to Wei-Guo Liu; 82001898 to Xi-Ze Jia; 81771820, 81371519 and 81571654 to Wei Luo), Henry G Leong Endowed Professorship in Neurology to Shu-Leong Ho and Shirley YY Pang, BRC for Mental Health at South London and Maudsley NHS Foundation Trust and by the Sackler Institute to Grainne McAlonan, NIH (2R01AG006457 to Fay B. Horak; 1RC4NS073008-01 and P50NS062684 to Tara Madhyastha), NINDS Intramural Research Program to Mark Hallett, Start-up Funds for Leading Talents at Beijing Normal University and National Basic Science Data Center ?Chinese Data-sharing Warehouse for In-vivo Imaging Brain? (NBSDC-DB-15) to Xi-Nian Zuo, and Grant NU20-04-00294 of the Agency for Health Research, Czech Republic to Lenka Krajcovicova and Irena Rektorova. We thank Dr. Chao Jiang from Capital Normal University for his assistance on figure-making.

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Jia, X. Z., Zhao, N., Dong, H. M., Sun, J. W., Barton, M., Burciu, R., Carrière, N., Cerasa, A., Chen, B. Y., Chen, J., Coombes, S., Defebvre, L., Delmaire, C., Dujardin, K., Esposito, F., Fan, G. G., Di Nardo, F., Feng, Y. X., Fling, B. W., ... Zang, Y. F. (2021). Small P values may not yield robust findings: an example using REST-meta-PD. Science Bulletin, 66(21), 2148-2152. https://doi.org/10.1016/j.scib.2021.06.007

@article{0d9b72c4cfd445c69533fc1a301818e0,

title = "Small P values may not yield robust findings: an example using REST-meta-PD",

author = "Jia, {Xi Ze} and Na Zhao and Dong, {Hao Ming} and Sun, {Jia Wei} and Marek Barton and Roxana Burciu and Nicolas Carri{\`e}re and Antonio Cerasa and Chen, {Bo Yu} and Jun Chen and Stephen Coombes and Luc Defebvre and Christine Delmaire and Kathy Dujardin and Fabrizio Esposito and Fan, {Guo Guang} and {Di Nardo}, Federica and Feng, {Yi Xuan} and Fling, {Brett W.} and Saurabh Garg and Moran Gilat and Martin Gorges and Ho, {Shu Leong} and Horak, {Fay B.} and Xiao Hu and Hu, {Xiao Fei} and Biao Huang and Huang, {Pei Yu} and Jia, {Ze Juan} and Christina Jones and Jan Kassubek and Lenka Krajcovicova and Ajay Kurani and Jing Li and Qing Li and Liu, {Ai Ping} and Bo Liu and Hu Liu and Liu, {Wei Guo} and Renaud Lopes and Lou, {Yu Ting} and Wei Luo and Tara Madhyastha and Mao, {Ni Ni} and Grainne McAlonan and McKeown, {Martin J.} and Shirley Pang and Andrea Quattrone and Irena Rektorova and Alessia Sarica and Shang, {Hui Fang} and Shine, {James M.} and Priyank Shukla and Tomas Slavicek and Song, {Xiao Peng} and Gioacchino Tedeschi and Alessandro Tessitore and David Vaillancourt and Jian Wang and Jue Wang and {Jane Wang}, Z. and Wei, {Lu Qing} and Xia Wu and Xu, {Xiao Jun} and Lei Yan and Jing Yang and Yang, {Wan Qun} and Yao, {Nai Lin} and Zhang, {De Long} and Zhang, {Jiu Quan} and Zhang, {Min Ming} and Zhang, {Yan Ling} and Zhou, {Cai Hong} and Yan, {Chao Gan} and Zuo, {Xi Nian} and Mark Hallett and Tao Wu and Zang, {Yu Feng}",

note = "Funding Information: We are grateful to all investigators who helped in data collection. This work was supported by the National Natural Science Foundation of China , China ( 81520108016 , 81661148045 , and 31471084 to Yu-Feng Zang; 81671774 and 81630031 to Chao-Gan Yan; 81571228 to Tao Wu; 61571047 to Xia Wu; 81701664 to Jian Wang, 81471654 to Biao Huang; 81701671 to Wei-Guo Liu; 82001898 to Xi-Ze Jia; 81771820 , 81371519 and 81571654 to Wei Luo), Henry G Leong Endowed Professorship in Neurology to Shu-Leong Ho and Shirley YY Pang, BRC for Mental Health at South London and Maudsley NHS Foundation Trust and by the Sackler Institute to Grainne McAlonan, NIH ( 2R01AG006457 to Fay B. Horak; 1RC4NS073008-01 and P50NS062684 to Tara Madhyastha), NINDS Intramural Research Program to Mark Hallett, Start-up Funds for Leading Talents at Beijing Normal University and National Basic Science Data Center “Chinese Data-sharing Warehouse for In-vivo Imaging Brain” (NBSDC-DB-15) to Xi-Nian Zuo, and Grant NU20-04-00294 of the Agency for Health Research, Czech Republic to Lenka Krajcovicova and Irena Rektorova. We thank Dr. Chao Jiang from Capital Normal University for his assistance on figure-making. Funding Information: We are grateful to all investigators who helped in data collection. This work was supported by the National Natural Science Foundation of China (81520108016, 81661148045, and 31471084 to Yu-Feng Zang; 81671774 and 81630031 to Chao-Gan Yan; 81571228 to Tao Wu; 61571047 to Xia Wu; 81701664 to Jian Wang, 81471654 to Biao Huang; 81701671 to Wei-Guo Liu; 82001898 to Xi-Ze Jia; 81771820, 81371519 and 81571654 to Wei Luo), Henry G Leong Endowed Professorship in Neurology to Shu-Leong Ho and Shirley YY Pang, BRC for Mental Health at South London and Maudsley NHS Foundation Trust and by the Sackler Institute to Grainne McAlonan, NIH (2R01AG006457 to Fay B. Horak; 1RC4NS073008-01 and P50NS062684 to Tara Madhyastha), NINDS Intramural Research Program to Mark Hallett, Start-up Funds for Leading Talents at Beijing Normal University and National Basic Science Data Center ?Chinese Data-sharing Warehouse for In-vivo Imaging Brain? (NBSDC-DB-15) to Xi-Nian Zuo, and Grant NU20-04-00294 of the Agency for Health Research, Czech Republic to Lenka Krajcovicova and Irena Rektorova. We thank Dr. Chao Jiang from Capital Normal University for his assistance on figure-making.",

year = "2021",

month = nov,

day = "15",

doi = "10.1016/j.scib.2021.06.007",

language = "English (US)",

volume = "66",

pages = "2148--2152",

journal = "Science Bulletin",

issn = "2095-9273",

publisher = "Elsevier B.V.",

number = "21",

}

Jia, XZ, Zhao, N, Dong, HM, Sun, JW, Barton, M, Burciu, R, Carrière, N, Cerasa, A, Chen, BY, Chen, J, Coombes, S, Defebvre, L, Delmaire, C, Dujardin, K, Esposito, F, Fan, GG, Di Nardo, F, Feng, YX, Fling, BW, Garg, S, Gilat, M, Gorges, M, Ho, SL, Horak, FB, Hu, X, Hu, XF, Huang, B, Huang, PY, Jia, ZJ, Jones, C, Kassubek, J, Krajcovicova, L, Kurani, A, Li, J, Li, Q, Liu, AP, Liu, B, Liu, H, Liu, WG, Lopes, R, Lou, YT, Luo, W, Madhyastha, T, Mao, NN, McAlonan, G, McKeown, MJ, Pang, S, Quattrone, A, Rektorova, I, Sarica, A, Shang, HF, Shine, JM, Shukla, P, Slavicek, T, Song, XP, Tedeschi, G, Tessitore, A, Vaillancourt, D, Wang, J, Wang, J, Jane Wang, Z, Wei, LQ, Wu, X, Xu, XJ, Yan, L, Yang, J, Yang, WQ, Yao, NL, Zhang, DL, Zhang, JQ, Zhang, MM, Zhang, YL, Zhou, CH, Yan, CG, Zuo, XN, Hallett, M, Wu, T & Zang, YF 2021, 'Small P values may not yield robust findings: an example using REST-meta-PD', Science Bulletin, vol. 66, no. 21, pp. 2148-2152. https://doi.org/10.1016/j.scib.2021.06.007

TY - JOUR

T1 - Small P values may not yield robust findings

T2 - an example using REST-meta-PD

AU - Jia, Xi Ze

AU - Zhao, Na

AU - Dong, Hao Ming

AU - Sun, Jia Wei

AU - Barton, Marek

AU - Burciu, Roxana

AU - Carrière, Nicolas

AU - Cerasa, Antonio

AU - Chen, Bo Yu

AU - Chen, Jun

AU - Coombes, Stephen

AU - Defebvre, Luc

AU - Delmaire, Christine

AU - Dujardin, Kathy

AU - Esposito, Fabrizio

AU - Fan, Guo Guang

AU - Di Nardo, Federica

AU - Feng, Yi Xuan

AU - Fling, Brett W.

AU - Garg, Saurabh

AU - Gilat, Moran

AU - Gorges, Martin

AU - Ho, Shu Leong

AU - Horak, Fay B.

AU - Hu, Xiao

AU - Hu, Xiao Fei

AU - Huang, Biao

AU - Huang, Pei Yu

AU - Jia, Ze Juan

AU - Jones, Christina

AU - Kassubek, Jan

AU - Krajcovicova, Lenka

AU - Kurani, Ajay

AU - Li, Jing

AU - Li, Qing

AU - Liu, Ai Ping

AU - Liu, Bo

AU - Liu, Hu

AU - Liu, Wei Guo

AU - Lopes, Renaud

AU - Lou, Yu Ting

AU - Luo, Wei

AU - Madhyastha, Tara

AU - Mao, Ni Ni

AU - McAlonan, Grainne

AU - McKeown, Martin J.

AU - Pang, Shirley

AU - Quattrone, Andrea

AU - Rektorova, Irena

AU - Sarica, Alessia

AU - Shang, Hui Fang

AU - Shine, James M.

AU - Shukla, Priyank

AU - Slavicek, Tomas

AU - Song, Xiao Peng

AU - Tedeschi, Gioacchino

AU - Tessitore, Alessandro

AU - Vaillancourt, David

AU - Wang, Jian

AU - Wang, Jue

AU - Jane Wang, Z.

AU - Wei, Lu Qing

AU - Wu, Xia

AU - Xu, Xiao Jun

AU - Yan, Lei

AU - Yang, Jing

AU - Yang, Wan Qun

AU - Yao, Nai Lin

AU - Zhang, De Long

AU - Zhang, Jiu Quan

AU - Zhang, Min Ming

AU - Zhang, Yan Ling

AU - Zhou, Cai Hong

AU - Yan, Chao Gan

AU - Zuo, Xi Nian

AU - Hallett, Mark

AU - Wu, Tao

AU - Zang, Yu Feng

N1 - Funding Information: We are grateful to all investigators who helped in data collection. This work was supported by the National Natural Science Foundation of China , China ( 81520108016 , 81661148045 , and 31471084 to Yu-Feng Zang; 81671774 and 81630031 to Chao-Gan Yan; 81571228 to Tao Wu; 61571047 to Xia Wu; 81701664 to Jian Wang, 81471654 to Biao Huang; 81701671 to Wei-Guo Liu; 82001898 to Xi-Ze Jia; 81771820 , 81371519 and 81571654 to Wei Luo), Henry G Leong Endowed Professorship in Neurology to Shu-Leong Ho and Shirley YY Pang, BRC for Mental Health at South London and Maudsley NHS Foundation Trust and by the Sackler Institute to Grainne McAlonan, NIH ( 2R01AG006457 to Fay B. Horak; 1RC4NS073008-01 and P50NS062684 to Tara Madhyastha), NINDS Intramural Research Program to Mark Hallett, Start-up Funds for Leading Talents at Beijing Normal University and National Basic Science Data Center “Chinese Data-sharing Warehouse for In-vivo Imaging Brain” (NBSDC-DB-15) to Xi-Nian Zuo, and Grant NU20-04-00294 of the Agency for Health Research, Czech Republic to Lenka Krajcovicova and Irena Rektorova. We thank Dr. Chao Jiang from Capital Normal University for his assistance on figure-making. Funding Information: We are grateful to all investigators who helped in data collection. This work was supported by the National Natural Science Foundation of China (81520108016, 81661148045, and 31471084 to Yu-Feng Zang; 81671774 and 81630031 to Chao-Gan Yan; 81571228 to Tao Wu; 61571047 to Xia Wu; 81701664 to Jian Wang, 81471654 to Biao Huang; 81701671 to Wei-Guo Liu; 82001898 to Xi-Ze Jia; 81771820, 81371519 and 81571654 to Wei Luo), Henry G Leong Endowed Professorship in Neurology to Shu-Leong Ho and Shirley YY Pang, BRC for Mental Health at South London and Maudsley NHS Foundation Trust and by the Sackler Institute to Grainne McAlonan, NIH (2R01AG006457 to Fay B. Horak; 1RC4NS073008-01 and P50NS062684 to Tara Madhyastha), NINDS Intramural Research Program to Mark Hallett, Start-up Funds for Leading Talents at Beijing Normal University and National Basic Science Data Center ?Chinese Data-sharing Warehouse for In-vivo Imaging Brain? (NBSDC-DB-15) to Xi-Nian Zuo, and Grant NU20-04-00294 of the Agency for Health Research, Czech Republic to Lenka Krajcovicova and Irena Rektorova. We thank Dr. Chao Jiang from Capital Normal University for his assistance on figure-making.

PY - 2021/11/15

Y1 - 2021/11/15

UR - http://www.scopus.com/inward/record.url?scp=85108523220&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85108523220&partnerID=8YFLogxK

U2 - 10.1016/j.scib.2021.06.007

DO - 10.1016/j.scib.2021.06.007

M3 - Comment/debate

C2 - 36654102

AN - SCOPUS:85108523220

SN - 2095-9273

VL - 66

SP - 2148

EP - 2152

JO - Science Bulletin

JF - Science Bulletin

IS - 21

ER -

Small P values may not yield robust findings: an example using REST-meta-PD

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