Smart lipids for programmable nanomaterials

Matthew P. Thompson, Miao Ping Chien, Ti Hsuan Ku, Anthony M. Rush, Nathan C. Gianneschi

Research output: Contribution to journalArticlepeer-review

62 Scopus citations


Novel, responsive liposomes are introduced, assembled from DNA-programmed lipids allowing sequence selective manipulation of nanoscale morphology. Short, single-stranded DNA sequences form polar head groups conjugated to hydrophobic tails. The morphology of the resulting lipid aggregates depends on sterics and electronics in the polar head groups and, therefore, is dependent on the DNA hybridization state. The programmability, specificity, and reversibility of the switchable system are demonstrated via dynamic light scattering, transmission electron microscopy, and fluorescence microscopy.

Original languageEnglish (US)
Pages (from-to)2690-2693
Number of pages4
JournalNano letters
Issue number7
StatePublished - Jul 14 2010


  • DNA
  • Lipids
  • Liposomes
  • Nanomaterials
  • Self-assembly
  • Stimuli-responsive

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering


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