SMN transcript stability: Could modulation of messenger RNA degradation provide a novel therapy for spinal muscular atrophy?

Keyphrases

• Novel Therapies 100%
• Messenger RNA (mRNA) 100%
• Spinal muscular Atrophy 100%
• SMN2 100%
• Transcript Stability 100%
• Acid Degradation 100%
• Alternative Splicing 33%
• SMN1 33%
• Exon 7 22%
• SMN1 Gene 22%
• Splicing Factor 11%
• Therapeutic Target 11%
• Skipping 11%
• Fibroblast Cells 11%
• Binding Site 11%
• Disease Mechanisms 11%
• Binding Protein 11%
• Therapeutic Modulation 11%
• Molecular Defects 11%
• Survival Motor Neuron 11%
• Protein Level 11%
• Ribonucleic Acid 11%
• Stop Codon 11%
• Single nucleotide 11%
• Truncated Protein 11%
• Transcription Inhibitors 11%
• Primary Fibroblasts 11%
• General Benefits 11%
• Proximal Spinal muscular Atrophy 11%
• SMN2 Gene 11%
• Acid Stability 11%

Immunology and Microbiology

• Alternative RNA Splicing 100%
• RNA Degradation 100%
• Exon 100%
• RNA Binding 50%
• RNA Stability 50%
• Protein Binding 50%
• Binding Site 50%
• Stop Codon 50%
• Fibroblast 50%

Neuroscience

• RNA Degradation 100%
• Messenger RNA 100%
• Spinal Muscular Atrophy 100%
• Alternative Splicing 40%
• Exon 40%
• Binding Site 20%
• Splicing Factor 20%
• Survival Motor Neuron Protein 20%
• RNA Stability 20%
• Stop Codon 20%
• RNA-binding Protein 20%
• Fibroblast 20%