TY - JOUR
T1 - Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation
AU - Kunchithapautham, Kannan
AU - Atkinson, Carl
AU - Rohrer, Bärbel
PY - 2014
Y1 - 2014
N2 - Background: Smoke components can generate 1) oxidative stress; 2) complement activation; 3) endoplasmic reticulum stress; and 4) lipid dysregulation. Results: In smoke-exposed RPE cells all four measures were activated, and reversed by antioxidants and blocking alternative complement pathway signaling. Conclusion: Oxidative stress and complement act synergistically in age-related macular degeneration (AMD) pathogenesis. Significance: Identifying mechanisms of lipid deposition will aid to develop new therapeutic approaches for AMD.
AB - Background: Smoke components can generate 1) oxidative stress; 2) complement activation; 3) endoplasmic reticulum stress; and 4) lipid dysregulation. Results: In smoke-exposed RPE cells all four measures were activated, and reversed by antioxidants and blocking alternative complement pathway signaling. Conclusion: Oxidative stress and complement act synergistically in age-related macular degeneration (AMD) pathogenesis. Significance: Identifying mechanisms of lipid deposition will aid to develop new therapeutic approaches for AMD.
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U2 - 10.1074/jbc.M114.564674
DO - 10.1074/jbc.M114.564674
M3 - Article
C2 - 24711457
AN - SCOPUS:84901398187
SN - 0021-9258
VL - 289
SP - 14534
EP - 14546
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 21
ER -