Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation

Kannan Kunchithapautham, Carl Atkinson, Bärbel Rohrer*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

140 Scopus citations

Abstract

Background: Smoke components can generate 1) oxidative stress; 2) complement activation; 3) endoplasmic reticulum stress; and 4) lipid dysregulation. Results: In smoke-exposed RPE cells all four measures were activated, and reversed by antioxidants and blocking alternative complement pathway signaling. Conclusion: Oxidative stress and complement act synergistically in age-related macular degeneration (AMD) pathogenesis. Significance: Identifying mechanisms of lipid deposition will aid to develop new therapeutic approaches for AMD.

Original languageEnglish (US)
Pages (from-to)14534-14546
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number21
DOIs
StatePublished - 2014

Funding

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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