Smoking increases risk of pain chronification through shared corticostriatal circuitry

Bogdan Petre, Souraya Torbey, James W Griffith, Gildasio S De Oliveira Jr, Kristine Herrmann, Ali Mansour, Alex T. Baria, Marwan N Baliki, Thomas J Schnitzer, Apkar Apkarian*

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Smoking is associated with increased incidence of chronic pain. However, the evidence is cross-sectional in nature, and underlying mechanisms remain unclear. In a longitudinal observational study, we examined the relationship between smoking, transition to chronic pain, and brain physiology. In 160 subjects with subacute back pain (SBP: back pain lasting 4-12 weeks, and no prior back pain [BP] for at least 1 year) pain characteristics, smoking status, and brain functional properties were measured repeatedly over 1 year. Sixty-eight completed the study, subdivided into recovering (SBPr, n=31) and persisting (SBPp, n=37), based on >20% decrease in BP over the year. Thirty-two chronic back pain (CBP: duration>5 years) and 35 healthy controls were similarly monitored. Smoking prevalence was higher in SBP and CBP but not related to intensity of BP. In SBP, smoking status at baseline was predictive of persistence of BP 1 year from symptom onset (differentiating SBPp and SBPr with 0.62 accuracy). Smoking status combined with affective properties of pain and medication use improved prediction accuracy (0.82). Mediation analysis indicated the prediction of BP persistence by smoking was largely due to synchrony of fMRI activity between two brain areas (nucleus accumbens and medial prefrontal cortex, NAc-mPFC). In SBP or CBP who ceased smoking strength of NAc-mPFC decreased from precessation to postcessation of smoking. We conclude that smoking increases risk of transitioning to CBP, an effect mediated by corticostriatal circuitry involved in addictive behavior and motivated learning.

Original languageEnglish (US)
Pages (from-to)683-694
Number of pages12
JournalHuman Brain Mapping
Volume36
Issue number2
DOIs
StatePublished - Feb 1 2015

Fingerprint

Back Pain
Smoking
Pain
Chronic Pain
Nucleus Accumbens
Prefrontal Cortex
Brain
Addictive Behavior
Observational Studies
Longitudinal Studies
Magnetic Resonance Imaging
Learning
Incidence

Keywords

  • Accumbens
  • Back pain
  • Chronic pain
  • FMRI
  • Prefrontal cortex
  • Smoking

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Petre, Bogdan ; Torbey, Souraya ; Griffith, James W ; De Oliveira Jr, Gildasio S ; Herrmann, Kristine ; Mansour, Ali ; Baria, Alex T. ; Baliki, Marwan N ; Schnitzer, Thomas J ; Apkarian, Apkar. / Smoking increases risk of pain chronification through shared corticostriatal circuitry. In: Human Brain Mapping. 2015 ; Vol. 36, No. 2. pp. 683-694.
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Smoking increases risk of pain chronification through shared corticostriatal circuitry. / Petre, Bogdan; Torbey, Souraya; Griffith, James W; De Oliveira Jr, Gildasio S; Herrmann, Kristine; Mansour, Ali; Baria, Alex T.; Baliki, Marwan N; Schnitzer, Thomas J; Apkarian, Apkar.

In: Human Brain Mapping, Vol. 36, No. 2, 01.02.2015, p. 683-694.

Research output: Contribution to journalArticle

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