SMYD3 promoter hypomethylation is associated with the risk of colorectal cancer

Bin Li; Ranran Pan; Cong Zhou; Jie Dai; Yiyi Mao; Min Chen; Tianyi Huang; Xiuru Ying; Haochang Hu; Jun Zhao; Wei Zhang; Shiwei Duan

doi:10.2217/fon-2017-0682

SMYD3 promoter hypomethylation is associated with the risk of colorectal cancer

Bin Li, Ranran Pan, Cong Zhou, Jie Dai, Yiyi Mao, Min Chen, Tianyi Huang, Xiuru Ying, Haochang Hu, Jun Zhao, Wei Zhang, Shiwei Duan^*

^*Corresponding author for this work

Preventive Medicine

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Aim:SMYD3 encodes histone lysine methyltransferase. The goal of our study was to investigate the association between SMYD3 methylation and colorectal cancer (CRC). Materials & methods: SMYD3 methylation was measured by quantitative methylation-specific PCR method in 117 pairs of CRC tumor and para-tumor tissues. Results: Significantly lower SMYD3 methylation was observed in CRC tumor tissues than para-tumor tissues (p = 0.002). Further subgroup analysis by clinical features showed that significantly lower SMYD3 methylation were only observed in the CRC patients with tumors of moderately and well differentiation, positive lymph node metastasis, and stage III + IV. Conclusion: Our work reported for the first time that SMYD3 promoter hypomethylation was associated with CRC.

Original language	English (US)
Pages (from-to)	1825-1834
Number of pages	10
Journal	Future Oncology
Volume	14
Issue number	18
DOIs	https://doi.org/10.2217/fon-2017-0682
State	Published - Aug 2018

Funding

The research is supported in part by KC Wong Magna Fund of the Ningbo University (to S Duan) and U01CA217078 (to W Zhang).

Keywords

DNA methylation
SMYD3
colorectal cancer
promoter
quantitative methylation-specific PCR

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2217/fon-2017-0682

Cite this

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title = "SMYD3 promoter hypomethylation is associated with the risk of colorectal cancer",

abstract = "Aim:SMYD3 encodes histone lysine methyltransferase. The goal of our study was to investigate the association between SMYD3 methylation and colorectal cancer (CRC). Materials & methods: SMYD3 methylation was measured by quantitative methylation-specific PCR method in 117 pairs of CRC tumor and para-tumor tissues. Results: Significantly lower SMYD3 methylation was observed in CRC tumor tissues than para-tumor tissues (p = 0.002). Further subgroup analysis by clinical features showed that significantly lower SMYD3 methylation were only observed in the CRC patients with tumors of moderately and well differentiation, positive lymph node metastasis, and stage III + IV. Conclusion: Our work reported for the first time that SMYD3 promoter hypomethylation was associated with CRC.",

keywords = "DNA methylation, SMYD3, colorectal cancer, promoter, quantitative methylation-specific PCR",

author = "Bin Li and Ranran Pan and Cong Zhou and Jie Dai and Yiyi Mao and Min Chen and Tianyi Huang and Xiuru Ying and Haochang Hu and Jun Zhao and Wei Zhang and Shiwei Duan",

note = "Funding Information: The research is supported in part by KC Wong Magna Fund of the Ningbo University (to S Duan) and U01CA217078 (to W Zhang). Publisher Copyright: {\textcopyright} 2018 2018 Future Medicine Ltd.",

year = "2018",

month = aug,

doi = "10.2217/fon-2017-0682",

language = "English (US)",

volume = "14",

pages = "1825--1834",

journal = "Future Oncology",

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T1 - SMYD3 promoter hypomethylation is associated with the risk of colorectal cancer

AU - Li, Bin

AU - Pan, Ranran

AU - Zhou, Cong

AU - Dai, Jie

AU - Mao, Yiyi

AU - Chen, Min

AU - Huang, Tianyi

AU - Ying, Xiuru

AU - Hu, Haochang

AU - Zhao, Jun

AU - Zhang, Wei

AU - Duan, Shiwei

N1 - Funding Information: The research is supported in part by KC Wong Magna Fund of the Ningbo University (to S Duan) and U01CA217078 (to W Zhang). Publisher Copyright: © 2018 2018 Future Medicine Ltd.

PY - 2018/8

Y1 - 2018/8

N2 - Aim:SMYD3 encodes histone lysine methyltransferase. The goal of our study was to investigate the association between SMYD3 methylation and colorectal cancer (CRC). Materials & methods: SMYD3 methylation was measured by quantitative methylation-specific PCR method in 117 pairs of CRC tumor and para-tumor tissues. Results: Significantly lower SMYD3 methylation was observed in CRC tumor tissues than para-tumor tissues (p = 0.002). Further subgroup analysis by clinical features showed that significantly lower SMYD3 methylation were only observed in the CRC patients with tumors of moderately and well differentiation, positive lymph node metastasis, and stage III + IV. Conclusion: Our work reported for the first time that SMYD3 promoter hypomethylation was associated with CRC.

AB - Aim:SMYD3 encodes histone lysine methyltransferase. The goal of our study was to investigate the association between SMYD3 methylation and colorectal cancer (CRC). Materials & methods: SMYD3 methylation was measured by quantitative methylation-specific PCR method in 117 pairs of CRC tumor and para-tumor tissues. Results: Significantly lower SMYD3 methylation was observed in CRC tumor tissues than para-tumor tissues (p = 0.002). Further subgroup analysis by clinical features showed that significantly lower SMYD3 methylation were only observed in the CRC patients with tumors of moderately and well differentiation, positive lymph node metastasis, and stage III + IV. Conclusion: Our work reported for the first time that SMYD3 promoter hypomethylation was associated with CRC.

KW - DNA methylation

KW - SMYD3

KW - colorectal cancer

KW - promoter

KW - quantitative methylation-specific PCR

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ER -

SMYD3 promoter hypomethylation is associated with the risk of colorectal cancer

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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