Snap-top nanocarriers

Michael W. Ambrogio; Travis A. Pecorelli; Kaushik Patel; Niveen M. Khashab; Ali Trabolsi; Hussam A. Khatib; Youssry Y. Botros; Jeffrey I. Zink; J. Fraser Stoddart

doi:10.1021/ol101286a

Snap-top nanocarriers

Michael W. Ambrogio, Travis A. Pecorelli, Kaushik Patel, Niveen M. Khashab, Ali Trabolsi, Hussam A. Khatib, Youssry Y. Botros, Jeffrey I. Zink, J. Fraser Stoddart

Chemistry

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

(Equation Presented). An approach to the design and fabrication of mechanized mesoporous silica nanoparticles is demonstrated at the proof of principle level. It relies on the reductive cleavage of disulfide bonds within an integrated nanosystem, wherein surface-bound rotaxanes incorporate disulfide bonds in their stalks,-which are encircled by cucurbit[6]uril or α-cyclodextrin rings, until reductive chemistry is performed, resulting in the snapping of the stalks of the rotaxanes, leading to cargo release from the inside of the nanoparticles.

Original language	English (US)
Pages (from-to)	3304-3307
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	15
DOIs	https://doi.org/10.1021/ol101286a
State	Published - Aug 6 2010

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol101286a

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title = "Snap-top nanocarriers",

abstract = "(Equation Presented). An approach to the design and fabrication of mechanized mesoporous silica nanoparticles is demonstrated at the proof of principle level. It relies on the reductive cleavage of disulfide bonds within an integrated nanosystem, wherein surface-bound rotaxanes incorporate disulfide bonds in their stalks,-which are encircled by cucurbit[6]uril or α-cyclodextrin rings, until reductive chemistry is performed, resulting in the snapping of the stalks of the rotaxanes, leading to cargo release from the inside of the nanoparticles.",

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year = "2010",

month = aug,

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doi = "10.1021/ol101286a",

language = "English (US)",

volume = "12",

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journal = "Organic Letters",

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AU - Ambrogio, Michael W.

AU - Pecorelli, Travis A.

AU - Patel, Kaushik

AU - Khashab, Niveen M.

AU - Trabolsi, Ali

AU - Khatib, Hussam A.

AU - Botros, Youssry Y.

AU - Zink, Jeffrey I.

AU - Stoddart, J. Fraser

PY - 2010/8/6

Y1 - 2010/8/6

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AB - (Equation Presented). An approach to the design and fabrication of mechanized mesoporous silica nanoparticles is demonstrated at the proof of principle level. It relies on the reductive cleavage of disulfide bonds within an integrated nanosystem, wherein surface-bound rotaxanes incorporate disulfide bonds in their stalks,-which are encircled by cucurbit[6]uril or α-cyclodextrin rings, until reductive chemistry is performed, resulting in the snapping of the stalks of the rotaxanes, leading to cargo release from the inside of the nanoparticles.

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JF - Organic Letters

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ER -

Snap-top nanocarriers

Abstract

ASJC Scopus subject areas

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