Abstract
Store operated Ca2+ entry (SOCE) is a ubiquitous signalling module with established roles in the immune system, secretion and muscle development. Recent evidence supports a complex role for SOCE in the nervous system. In this review we present an update of the current knowledge on SOCE function in the brain with a focus on its role as a regulator of brain activity and excitability (Figure presented.).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1449-1462 |
| Number of pages | 14 |
| Journal | Journal of physiology |
| Volume | 602 |
| Issue number | 8 |
| DOIs | |
| State | Published - Apr 15 2024 |
Funding
Work in the Machaca Lab related to the subject of this review is funded by the Biomedical Research Program at Weill Cornell Medical College in Qatar (BMRP), a programme funded by Qatar Foundation, as well as by a grant from the Qatar National Research Fund (QNRF), grant number NPRP12S\u20100212\u2010190074. Other studies in the Machaca Lab are funded by grants from QNRF PPM04\u20100128\u2010200015 and NPRP13S\u20100206\u2010200274. Work in the Prakriya Lab is funded by National Institutes of Health grants R01NS057499 and R01NS115508. The statements made herein are solely the responsibility of the authors. Open access funding was provided by the Qatar National Library.
Keywords
- SOCE
- calcium signalling
- neuronal activity
ASJC Scopus subject areas
- Physiology