Social and Financial Outcomes of Living Liver Donation: A Prospective Investigation Within the Adult-to-Adult Living Donor Liver Transplantation Cohort Study 2 (A2ALL-2)

A. DiMartini*, M. A. Dew, Q. Liu, M. A. Simpson, D. P. Ladner, A. R. Smith, J. Zee, S. Abbey, B. W. Gillespie, R. Weinrieb, M. S. Mandell, R. A. Fisher, J. C. Emond, C. E. Freise, A. H. Sherker, Z. Butt

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Because results from single-center (mostly kidney) donor studies demonstrate interpersonal relationship and financial strains for some donors, we conducted a liver donor study involving nine centers within the Adult-to-Adult Living Donor Liver Transplantation Cohort Study 2 (A2ALL-2) consortium. Among other initiatives, A2ALL-2 examined the nature of these outcomes following donation. Using validated measures, donors were prospectively surveyed before donation and at 3, 6, 12, and 24 mo after donation. Repeated-measures regression models were used to examine social relationship and financial outcomes over time and to identify relevant predictors. Of 297 eligible donors, 271 (91%) consented and were interviewed at least once. Relationship changes were positive overall across postdonation time points, with nearly one-third reporting improved donor family and spousal or partner relationships and >50% reporting improved recipient relationships. The majority of donors, however, reported cumulative out-of-pocket medical and nonmedical expenses, which were judged burdensome by 44% of donors. Lower income predicted burdensome donation costs. Those who anticipated financial concerns and who held nonprofessional positions before donation were more likely to experience adverse financial outcomes. These data support the need for initiatives to reduce financial burden.

Original languageEnglish (US)
Pages (from-to)1081-1096
Number of pages16
JournalAmerican Journal of Transplantation
Volume17
Issue number4
DOIs
StatePublished - Apr 1 2017

Keywords

  • basic (laboratory) research/science
  • donors and donation: donor follow-up
  • donors and donation: living
  • income
  • liver transplantation/hepatology
  • liver transplantation: living donor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation
  • Pharmacology (medical)

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