@article{3b74e1e520a946eeb2e83beafead4faa,
title = "Social ecological predictors of longitudinal HIV treatment adherence in youth with perinatally acquired HIV",
abstract = "Objective To apply a social ecological model to explore the psychosocial factors prospectively associated with longitudinal adherence to antiretroviral treatment in youth perinatally infected with HIV. Methods Randomly selected youth, age 8 to <19 years old, completed cognitive testing and psychosocial questionnaires at baseline as part of a multisite protocol (N = 138). A validated caregiver-report measure of adherence was completed at baseline and 24 and 48 weeks after baseline. Results In multivariate analysis, youth awareness of HIV status, caregiver not fully responsible for medications, low caregiver well-being, adolescent perceptions of poor caregiver-youth relations, caregiver perceptions of low social support, and African American ethnicity were associated with nonadherence over 48 weeks. Conclusions Interventions focusing on caregivers and their interactions with the individual youth and extrafamilial system should be prioritized for prevention and treatment efforts to address nonadherence during the transition into adolescents.",
keywords = "HIV, antiretroviral therapy, children, patient adherence",
author = "Sylvie Naar-King and Grace Montepiedra and Patricia Garvie and Betsy Kammerer and Kathleen Malee and Sirois, {Patricia A.} and Lisa Aaron and Nichols, {Sharon L.}",
note = "Funding Information: Overall support for the International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT) was provided by the National Institute of Allergy and Infectious Diseases (NIAID) (U01 AI068632), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and the National Institute of Mental Health (NIMH) (AI068632). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. This work was supported by the Statistical and Data Analysis Center at Harvard School of Public Health, under the National Institute of Allergy and Infectious Diseases cooperative agreement #5 U01 AI41110 with the Pediatric AIDS Clinical Trials Group (PACTG) and #1 U01 AI068616 with the IMPAACT Group. Support of the sites was provided by the National Institute of Allergy and Infectious Diseases (NIAID) and the NICHD International and Domestic Pediatric and Maternal HIV Clinical Trials Network funded by NICHD (contract number N01-DK-9-001/HHSN267200800001C). The study was funded by the United States National Institute of Allergy and Infectious Diseases and the National Institute of Child Health and Human Development. These institutions were involved in the design, data collection, and conduct of protocol P1042S, but were not involved in the present analysis, the interpretation of the data, the writing of the manuscript, or the decision to submit for publication. Additional funding was provided by the William T. Grant Foundation. This work was supported by the Statistical and Data Analysis Center (SDAC) of the Pediatric AIDS Clinical Trials Group at Harvard School of Public Health, under the National Institute of Allergy and Infectious Diseases cooperative agreement No. 5 01 AI41110.",
year = "2013",
month = jul,
doi = "10.1093/jpepsy/jst017",
language = "English (US)",
volume = "38",
pages = "664--674",
journal = "Journal of Pediatric Psychology",
issn = "0146-8693",
publisher = "Oxford University Press",
number = "6",
}
