Social relationships and immune processes in HIV seropositive gay and bisexual men

Gregory E. Miller*, Margaret E. Kemeny, Shelley E. Taylor, Steve W. Cole, Barbara R. Visscher

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Scopus citations


This three-year longitudinal study assessed the association between social relationships and human immunodeficiency virus (HIV) progression in individuals at risk for morbidity and mortal ity due to acquired immune deficiency syndrome (AIDS). Two-hundred five HIV seropositive men without AIDS completed measures of social integration and loneliness at baseline. Blood samples used to assess CD4 T-lymphocyte levels were collected at baseline and at six-month intervals for a three-year follow-up period. Contrary to expectation, lower levels of baseline loneliness predicted more rapid declines in CD4 levels over the follow-up period. This association was independent of baseline CD4 values, negative affect, and health practices. A series of mediational analyses revealed that sexual behavior, medication use, bereavement, coping, and a number of other variables were not mechanisms through which loneliness affected the immune system. Loneliness was not associated with time to AIDS diagnosis or time to AIDS-related mortality. These findings are consistent with the emerging view that social relationships can have deleterious, as well as protective, influences on health outcomes.

Original languageEnglish (US)
Pages (from-to)139-151
Number of pages13
JournalAnnals of Behavioral Medicine
Issue number2
StatePublished - 1997

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • General Psychology


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