Social Support Mitigates Negative Impact of Food Insecurity on Antiretroviral Adherence Among Postpartum Women in Western Kenya

Mira Wang, Joshua D. Miller, Shalean M. Collins, Marianne V. Santoso, Pauline Wekesa, Hideaki Okochi, Maricianah Onono, Sheri Weiser, Monica Gandhi, Sera L. Young*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Food insecurity (FI), low social support, and low health-related quality of life (HRQoL) are associated with self-reported nonadherence to antiretroviral therapy (ART) among postpartum women, but these relationships have not been evaluated using objective adherence indicators. Hair samples were therefore analyzed among 83 postpartum Kenyan women living with HIV on efavirenz and nevirapine ART drug regimens in an observational cohort (NCT02974972). FI (0–27), social support (0–40), and HRQoL (8–40) in the prior month were also assessed. In multivariable models, each point increase in FI and decrease in HRQoL were associated with a 45.1% (95% CI: −64.3%, −15.6%) and 10.5% decrease (95% CI: 1.0%, 22.1%) in hair ART drug concentrations respectively, when social support was held constant. A significant interaction between social support and FI (β = 0.02, p = 0.017) indicated that greater social support was predicted to mitigate the negative impacts of FI on ART adherence. Addressing these modifiable barriers could improve ART adherence during this critical period.

Original languageEnglish (US)
Pages (from-to)2885-2894
Number of pages10
JournalAIDS and behavior
Volume24
Issue number10
DOIs
StatePublished - Oct 1 2020

Keywords

  • Antiretroviral adherence
  • Food insecurity
  • Hair ART drug concentrations
  • Postpartum
  • Social support

ASJC Scopus subject areas

  • Social Psychology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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    Wang, M., Miller, J. D., Collins, S. M., Santoso, M. V., Wekesa, P., Okochi, H., Onono, M., Weiser, S., Gandhi, M., & Young, S. L. (2020). Social Support Mitigates Negative Impact of Food Insecurity on Antiretroviral Adherence Among Postpartum Women in Western Kenya. AIDS and behavior, 24(10), 2885-2894. https://doi.org/10.1007/s10461-020-02839-9