Society for Immunotherapy of Cancer (SITC) clinical practice guideline on immunotherapy for the treatment of urothelial cancer

Matthew D. Galsky, Arjun V. Balar, Peter C. Black, Matthew T. Campbell, Gail S. Dykstra, Petros Grivas, Shilpa Gupta, Christoper J. Hoimes, Lidia P. Lopez, Joshua J. Meeks, Elizabeth R. Plimack, Jonathan E. Rosenberg, Neal Shore, Gary D. Steinberg, Ashish M. Kamat*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A number of immunotherapies have been developed and adopted for the treatment of urothelial cancer (encompassing cancers arising from the bladder, urethra, or renal pelvis). For these immunotherapies to positively impact patient outcomes, optimal selection of agents and treatment scheduling, especially in conjunction with existing treatment paradigms, is paramount. Immunotherapies also warrant specific and unique considerations regarding patient management, emphasizing both the prompt identification and treatment of potential toxicities. In order to address these issues, the Society for Immunotherapy of Cancer (SITC) convened a panel of experts in the field of immunotherapy for urothelial cancer. The expert panel developed this clinical practice guideline (CPG) to inform healthcare professionals on important aspects of immunotherapeutic treatment for urothelial cancer, including diagnostic testing, treatment planning, immune-related adverse events (irAEs), and patient quality of life (QOL) considerations. The evidence- and consensus-based recommendations in this CPG are intended to give guidance to cancer care providers treating patients with urothelial cancer.

Original languageEnglish (US)
Article numbere002552
JournalJournal for immunotherapy of cancer
Issue number7
StatePublished - Jul 15 2021


  • antineoplastic protocols
  • guidelines as topic
  • immunotherapy
  • urinary bladder neoplasms
  • urologic neoplasms

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Molecular Medicine
  • Oncology
  • Pharmacology
  • Cancer Research


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