Sociodemographic and Clinical Factors Associated With Clinical Outcome in Neuroinfectious Diseases: A Multicenter Retrospective Cohort Study

Alexandra Boubour; Carla Y. Kim; Sarah Torres; Dan T. Jia; Evan Hess; Sibei Liu; Yifei Sun; Kathryn Fong; Samantha Epstein; Helena Yan; Nicole Luche; Kerry Gao; Brittany Glassberg; Michael Harmon; Hai Hoang; Allison Navis; Emily Schorr; Jacqueline S. Gofshteyn; Anusha K. Yeshokumar; Kiran T. Thakur

doi:10.1177/19418744241263138

Sociodemographic and Clinical Factors Associated With Clinical Outcome in Neuroinfectious Diseases: A Multicenter Retrospective Cohort Study

Alexandra Boubour, Carla Y. Kim, Sarah Torres, Dan T. Jia, Evan Hess, Sibei Liu, Yifei Sun, Kathryn Fong, Samantha Epstein, Helena Yan, Nicole Luche, Kerry Gao, Brittany Glassberg, Michael Harmon, Hai Hoang, Allison Navis, Emily Schorr, Jacqueline S. Gofshteyn, Anusha K. Yeshokumar, Kiran T. Thakur^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To evaluate sociodemographic and clinical factors associated with clinical outcomes in patients hospitalized with neuroinfectious diseases at three tertiary care centers in New York City. Methods: This retrospective cohort study was conducted at three large urban tertiary care centers between January 1, 2010 and December 31, 2017. Poor clinical outcome was defined as length of hospital stay (LOS) ≥2 weeks and/or discharge to a location other than home. Sociodemographic and clinical factors were obtained from electronic medical records and descriptively analyzed. Multivariate logistic regression analysis investigated relationships between sociodemographic and clinical factors, and outcomes. Results: Among 205 patients with definitive neuroinfectious diagnoses, older patients were more likely to have a LOS ≥2 weeks (odds ratio [OR]: 1.03; 95% confidence interval [CI]: 1.01-1.05) and less likely to be discharged home (OR: 0.96; 95% CI: 0.94-0.98) than younger patients. Patients with an immunocompromised state were more likely to have a LOS ≥2 weeks (OR: 2.80; 95% CI: 1.17-6.69). Additionally, patients admitted to the intensive care unit (ICU) were more likely to have a LOS ≥2 weeks (OR: 4.65; 95% CI: 2.13-10.16) and less likely to be discharged home (OR: 0.14; 95% CI: 0.06-0.34). There were no statistically significant associations between sex, race, ethnicity, English proficiency, substance use, or poverty index, and clinical outcome. Conclusions: In this multicenter cohort of hospitalized neuroinfectious diseases, older age, history of immunocompromised state, and admission to the ICU were significantly associated with poor clinical outcome.

Original language	English (US)
Pages (from-to)	396-405
Number of pages	10
Journal	Neurohospitalist
Volume	14
Issue number	4
DOIs	https://doi.org/10.1177/19418744241263138
State	Published - Oct 2024

Funding

We are thankful for the support of Sajjad Abedian, the Cohort Discovery program (i2b2), and the Weill Cornell Clinical and Translational Science Center (CTSC). The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the following grants: Thakur \u2013 NIH/NINDS (5K23NS105935-03); Gofshteyn \u2013 NIH-NINDS K12 (NS066274-10).

Keywords

central nervous system bacterial infections
central nervous system infections
central nervous system viral diseases
outcomes

ASJC Scopus subject areas

Clinical Neurology

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10.1177/19418744241263138

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Boubour, A., Kim, C. Y., Torres, S., Jia, D. T., Hess, E., Liu, S., Sun, Y., Fong, K., Epstein, S., Yan, H., Luche, N., Gao, K., Glassberg, B., Harmon, M., Hoang, H., Navis, A., Schorr, E., Gofshteyn, J. S., Yeshokumar, A. K., & Thakur, K. T. (2024). Sociodemographic and Clinical Factors Associated With Clinical Outcome in Neuroinfectious Diseases: A Multicenter Retrospective Cohort Study. Neurohospitalist, 14(4), 396-405. https://doi.org/10.1177/19418744241263138

@article{84fcf1b0e5af4f5a8153ea59d38fbf7d,

title = "Sociodemographic and Clinical Factors Associated With Clinical Outcome in Neuroinfectious Diseases: A Multicenter Retrospective Cohort Study",

abstract = "Objective: To evaluate sociodemographic and clinical factors associated with clinical outcomes in patients hospitalized with neuroinfectious diseases at three tertiary care centers in New York City. Methods: This retrospective cohort study was conducted at three large urban tertiary care centers between January 1, 2010 and December 31, 2017. Poor clinical outcome was defined as length of hospital stay (LOS) ≥2 weeks and/or discharge to a location other than home. Sociodemographic and clinical factors were obtained from electronic medical records and descriptively analyzed. Multivariate logistic regression analysis investigated relationships between sociodemographic and clinical factors, and outcomes. Results: Among 205 patients with definitive neuroinfectious diagnoses, older patients were more likely to have a LOS ≥2 weeks (odds ratio [OR]: 1.03; 95% confidence interval [CI]: 1.01-1.05) and less likely to be discharged home (OR: 0.96; 95% CI: 0.94-0.98) than younger patients. Patients with an immunocompromised state were more likely to have a LOS ≥2 weeks (OR: 2.80; 95% CI: 1.17-6.69). Additionally, patients admitted to the intensive care unit (ICU) were more likely to have a LOS ≥2 weeks (OR: 4.65; 95% CI: 2.13-10.16) and less likely to be discharged home (OR: 0.14; 95% CI: 0.06-0.34). There were no statistically significant associations between sex, race, ethnicity, English proficiency, substance use, or poverty index, and clinical outcome. Conclusions: In this multicenter cohort of hospitalized neuroinfectious diseases, older age, history of immunocompromised state, and admission to the ICU were significantly associated with poor clinical outcome.",

keywords = "central nervous system bacterial infections, central nervous system infections, central nervous system viral diseases, outcomes",

author = "Alexandra Boubour and Kim, {Carla Y.} and Sarah Torres and Jia, {Dan T.} and Evan Hess and Sibei Liu and Yifei Sun and Kathryn Fong and Samantha Epstein and Helena Yan and Nicole Luche and Kerry Gao and Brittany Glassberg and Michael Harmon and Hai Hoang and Allison Navis and Emily Schorr and Gofshteyn, {Jacqueline S.} and Yeshokumar, {Anusha K.} and Thakur, {Kiran T.}",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",

year = "2024",

month = oct,

doi = "10.1177/19418744241263138",

language = "English (US)",

volume = "14",

pages = "396--405",

journal = "Neurohospitalist",

issn = "1941-8744",

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Boubour, A, Kim, CY, Torres, S, Jia, DT, Hess, E, Liu, S, Sun, Y, Fong, K, Epstein, S, Yan, H, Luche, N, Gao, K, Glassberg, B, Harmon, M, Hoang, H, Navis, A, Schorr, E, Gofshteyn, JS, Yeshokumar, AK & Thakur, KT 2024, 'Sociodemographic and Clinical Factors Associated With Clinical Outcome in Neuroinfectious Diseases: A Multicenter Retrospective Cohort Study', Neurohospitalist, vol. 14, no. 4, pp. 396-405. https://doi.org/10.1177/19418744241263138

TY - JOUR

T1 - Sociodemographic and Clinical Factors Associated With Clinical Outcome in Neuroinfectious Diseases

T2 - A Multicenter Retrospective Cohort Study

AU - Boubour, Alexandra

AU - Kim, Carla Y.

AU - Torres, Sarah

AU - Jia, Dan T.

AU - Hess, Evan

AU - Liu, Sibei

AU - Sun, Yifei

AU - Fong, Kathryn

AU - Epstein, Samantha

AU - Yan, Helena

AU - Luche, Nicole

AU - Gao, Kerry

AU - Glassberg, Brittany

AU - Harmon, Michael

AU - Hoang, Hai

AU - Navis, Allison

AU - Schorr, Emily

AU - Gofshteyn, Jacqueline S.

AU - Yeshokumar, Anusha K.

AU - Thakur, Kiran T.

PY - 2024/10

Y1 - 2024/10

N2 - Objective: To evaluate sociodemographic and clinical factors associated with clinical outcomes in patients hospitalized with neuroinfectious diseases at three tertiary care centers in New York City. Methods: This retrospective cohort study was conducted at three large urban tertiary care centers between January 1, 2010 and December 31, 2017. Poor clinical outcome was defined as length of hospital stay (LOS) ≥2 weeks and/or discharge to a location other than home. Sociodemographic and clinical factors were obtained from electronic medical records and descriptively analyzed. Multivariate logistic regression analysis investigated relationships between sociodemographic and clinical factors, and outcomes. Results: Among 205 patients with definitive neuroinfectious diagnoses, older patients were more likely to have a LOS ≥2 weeks (odds ratio [OR]: 1.03; 95% confidence interval [CI]: 1.01-1.05) and less likely to be discharged home (OR: 0.96; 95% CI: 0.94-0.98) than younger patients. Patients with an immunocompromised state were more likely to have a LOS ≥2 weeks (OR: 2.80; 95% CI: 1.17-6.69). Additionally, patients admitted to the intensive care unit (ICU) were more likely to have a LOS ≥2 weeks (OR: 4.65; 95% CI: 2.13-10.16) and less likely to be discharged home (OR: 0.14; 95% CI: 0.06-0.34). There were no statistically significant associations between sex, race, ethnicity, English proficiency, substance use, or poverty index, and clinical outcome. Conclusions: In this multicenter cohort of hospitalized neuroinfectious diseases, older age, history of immunocompromised state, and admission to the ICU were significantly associated with poor clinical outcome.

AB - Objective: To evaluate sociodemographic and clinical factors associated with clinical outcomes in patients hospitalized with neuroinfectious diseases at three tertiary care centers in New York City. Methods: This retrospective cohort study was conducted at three large urban tertiary care centers between January 1, 2010 and December 31, 2017. Poor clinical outcome was defined as length of hospital stay (LOS) ≥2 weeks and/or discharge to a location other than home. Sociodemographic and clinical factors were obtained from electronic medical records and descriptively analyzed. Multivariate logistic regression analysis investigated relationships between sociodemographic and clinical factors, and outcomes. Results: Among 205 patients with definitive neuroinfectious diagnoses, older patients were more likely to have a LOS ≥2 weeks (odds ratio [OR]: 1.03; 95% confidence interval [CI]: 1.01-1.05) and less likely to be discharged home (OR: 0.96; 95% CI: 0.94-0.98) than younger patients. Patients with an immunocompromised state were more likely to have a LOS ≥2 weeks (OR: 2.80; 95% CI: 1.17-6.69). Additionally, patients admitted to the intensive care unit (ICU) were more likely to have a LOS ≥2 weeks (OR: 4.65; 95% CI: 2.13-10.16) and less likely to be discharged home (OR: 0.14; 95% CI: 0.06-0.34). There were no statistically significant associations between sex, race, ethnicity, English proficiency, substance use, or poverty index, and clinical outcome. Conclusions: In this multicenter cohort of hospitalized neuroinfectious diseases, older age, history of immunocompromised state, and admission to the ICU were significantly associated with poor clinical outcome.

KW - central nervous system bacterial infections

KW - central nervous system infections

KW - central nervous system viral diseases

KW - outcomes

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Sociodemographic and Clinical Factors Associated With Clinical Outcome in Neuroinfectious Diseases: A Multicenter Retrospective Cohort Study

Abstract

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