SODIUM CHANNELOPATHIES OF THE CENTRAL NERVOUS SYSTEM

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

This chapter presents information about the structure, function, and molecular genetics of voltage-gated sodium channels expressed in the central nervous system. Sodium channels are essential for the generation and propagation of neuronal action potentials. Recent advances in structural biology have provided atomic-scale descriptions of sodium channel structure that can be related to specific functional properties. We further discuss cellular and subcellular localization, as well as the primary physiological functions mediated by sodium channels within the central nervous system. Finally, this chapter examines the association of various sodium channel isoforms with common brain disorders, including epilepsy, autism, and migraine, and explains the range of functional consequences of disease-associated mutations that are correlated with diverse human phenotypes.

Original languageEnglish (US)
Title of host publicationThe Oxford Handbook of Neuronal Ion Channels
PublisherOxford University Press
Pages257-288
Number of pages32
ISBN (Electronic)9780190669171
ISBN (Print)9780190669164
DOIs
StatePublished - Jan 1 2018

Keywords

  • autism spectrum disorder
  • epilepsy
  • ion channel structure
  • migraine
  • sodium channel

ASJC Scopus subject areas

  • General Neuroscience

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