Sodium channels and neurological disease: Insights from Scn8a mutations in the mouse

Keyphrases

• Neurological Diseases 100%
• SCN8A 100%
• Sodium Channel mutation 100%
• Human Disease 40%
• High-throughput 20%
• Mouse Model 20%
• Mutant Mice 20%
• Pathophysiology 20%
• Screening Method 20%
• Ataxia 20%
• Null mutation 20%
• Dystonia 20%
• Human Genome 20%
• Paralysis 20%
• Muscle Weakness 20%
• Disease-causing mutations 20%
• Modifier Genes 20%
• Tremor 20%
• Motor Neuron 20%
• Sodium Channel Gene 20%
• Sodium Current 20%
• Voltage-gated Sodium Channel Gene 20%
• Human mutations 20%
• Human Genome Sequencing 20%
• Mode of Inheritance 20%
• Mutation Screening 20%
• Failure Loss 20%
• Channel Properties 20%
• Inheritance Factor 20%
• Neuromuscular Transmission 20%
• Xenopus Oocyte Expression System 20%

Biochemistry, Genetics and Molecular Biology

• Sodium Channel 100%
• Human Genome 50%
• Mouse Model 25%
• Screening 25%
• Allele 25%
• Xenopus 25%
• Electric Potential 25%
• Mouse Mutant 25%
• Modifier Gene 25%
• Motor Neuron 25%
• Sodium Current 25%
• Gene Expression System 25%
• Neuromuscular Transmission 25%