Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology

Zhiyuan Chen; Zexu Lin; Sofian N. Obaid; Eric Rytkin; Sharon A. George; Christopher Bach; Micah Madrid; Miya Liu; Jessica LaPiano; Amy Fehr; Xinyu Shi; Nathaniel Quirion; Benjamin Russo; Helen Knight; Anthony Aduwari; Igor R. Efimov; Luyao Lu

doi:10.1126/sciadv.adi0757

Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology

Zhiyuan Chen, Zexu Lin, Sofian N. Obaid, Eric Rytkin, Sharon A. George, Christopher Bach, Micah Madrid, Miya Liu, Jessica LaPiano, Amy Fehr, Xinyu Shi, Nathaniel Quirion, Benjamin Russo, Helen Knight, Anthony Aduwari, Igor R. Efimov^*, Luyao Lu^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Transparent microelectrode arrays (MEAs) that allow multimodal investigation of the spatiotemporal cardiac characteristics are important in studying and treating heart disease. Existing implantable devices, however, are designed to support chronic operational lifetimes and require surgical extraction when they malfunction or are no longer needed. Meanwhile, bioresorbable systems that can self-eliminate after performing temporary functions are increasingly attractive because they avoid the costs/risks of surgical extraction. We report the design, fabrication, characterization, and validation of a soft, fully bioresorbable, and transparent MEA platform for bidirectional cardiac interfacing over a clinically relevant period. The MEA provides multiparametric electrical/ optical mapping of cardiac dynamics and on-demand site-specific pacing to investigate and treat cardiac dysfunctions in rat and human heart models. The bioresorption dynamics and biocompatibility are investigated. The device designs serve as the basis for bioresorbable cardiac technologies for potential postsurgical monitoring and treating temporary patient pathological conditions in certain clinical scenarios, such as myocardial infarction, ischemia, and transcatheter aortic valve replacement.

Original language	English (US)
Article number	adi0757
Journal	Science Advances
Volume	9
Issue number	27
DOIs	https://doi.org/10.1126/sciadv.adi0757
State	Published - Jul 7 2023

Funding

Acknowledgments Funding: This project was supported by the NSF (2011093 and 2131682 to L.L. and I.R.E.) and the NIH (R01 HL141470 to I.R.E.). Author contributions: Conceptualization: Z.C., Z.L., I.R.E., and L.L. Methodology: Z.C., Z.L., and J.L. Investigation: Z.C., Z.L., S.N.O., E.R., S.A.G., C.B., M.M., B.R., and H.K. Fabrication: Z.C., C.B., M.L., A.F ., X.S., N.Q., and A.A. Visualization: Z.C., Z.L., and S.A.G. Supervision: I.R.E. and L.L. Writing: Z.C., Z.L., I.R.E., and L.L. Competing interests: The authors declare that they hav e no competing interests. Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the Supplementary Materials.

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Chen, Z., Lin, Z., Obaid, S. N., Rytkin, E., George, S. A., Bach, C., Madrid, M., Liu, M., LaPiano, J., Fehr, A., Shi, X., Quirion, N., Russo, B., Knight, H., Aduwari, A., Efimov, I. R., & Lu, L. (2023). Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology. Science Advances, 9(27), Article adi0757. https://doi.org/10.1126/sciadv.adi0757

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title = "Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology",

abstract = "Transparent microelectrode arrays (MEAs) that allow multimodal investigation of the spatiotemporal cardiac characteristics are important in studying and treating heart disease. Existing implantable devices, however, are designed to support chronic operational lifetimes and require surgical extraction when they malfunction or are no longer needed. Meanwhile, bioresorbable systems that can self-eliminate after performing temporary functions are increasingly attractive because they avoid the costs/risks of surgical extraction. We report the design, fabrication, characterization, and validation of a soft, fully bioresorbable, and transparent MEA platform for bidirectional cardiac interfacing over a clinically relevant period. The MEA provides multiparametric electrical/ optical mapping of cardiac dynamics and on-demand site-specific pacing to investigate and treat cardiac dysfunctions in rat and human heart models. The bioresorption dynamics and biocompatibility are investigated. The device designs serve as the basis for bioresorbable cardiac technologies for potential postsurgical monitoring and treating temporary patient pathological conditions in certain clinical scenarios, such as myocardial infarction, ischemia, and transcatheter aortic valve replacement.",

author = "Zhiyuan Chen and Zexu Lin and Obaid, {Sofian N.} and Eric Rytkin and George, {Sharon A.} and Christopher Bach and Micah Madrid and Miya Liu and Jessica LaPiano and Amy Fehr and Xinyu Shi and Nathaniel Quirion and Benjamin Russo and Helen Knight and Anthony Aduwari and Efimov, {Igor R.} and Luyao Lu",

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doi = "10.1126/sciadv.adi0757",

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Chen, Z, Lin, Z, Obaid, SN, Rytkin, E, George, SA, Bach, C, Madrid, M, Liu, M, LaPiano, J, Fehr, A, Shi, X, Quirion, N, Russo, B, Knight, H, Aduwari, A, Efimov, IR & Lu, L 2023, 'Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology', Science Advances, vol. 9, no. 27, adi0757. https://doi.org/10.1126/sciadv.adi0757

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AU - Chen, Zhiyuan

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AU - Rytkin, Eric

AU - George, Sharon A.

AU - Bach, Christopher

AU - Madrid, Micah

AU - Liu, Miya

AU - LaPiano, Jessica

AU - Fehr, Amy

AU - Shi, Xinyu

AU - Quirion, Nathaniel

AU - Russo, Benjamin

AU - Knight, Helen

AU - Aduwari, Anthony

AU - Efimov, Igor R.

AU - Lu, Luyao

PY - 2023/7/7

Y1 - 2023/7/7

N2 - Transparent microelectrode arrays (MEAs) that allow multimodal investigation of the spatiotemporal cardiac characteristics are important in studying and treating heart disease. Existing implantable devices, however, are designed to support chronic operational lifetimes and require surgical extraction when they malfunction or are no longer needed. Meanwhile, bioresorbable systems that can self-eliminate after performing temporary functions are increasingly attractive because they avoid the costs/risks of surgical extraction. We report the design, fabrication, characterization, and validation of a soft, fully bioresorbable, and transparent MEA platform for bidirectional cardiac interfacing over a clinically relevant period. The MEA provides multiparametric electrical/ optical mapping of cardiac dynamics and on-demand site-specific pacing to investigate and treat cardiac dysfunctions in rat and human heart models. The bioresorption dynamics and biocompatibility are investigated. The device designs serve as the basis for bioresorbable cardiac technologies for potential postsurgical monitoring and treating temporary patient pathological conditions in certain clinical scenarios, such as myocardial infarction, ischemia, and transcatheter aortic valve replacement.

AB - Transparent microelectrode arrays (MEAs) that allow multimodal investigation of the spatiotemporal cardiac characteristics are important in studying and treating heart disease. Existing implantable devices, however, are designed to support chronic operational lifetimes and require surgical extraction when they malfunction or are no longer needed. Meanwhile, bioresorbable systems that can self-eliminate after performing temporary functions are increasingly attractive because they avoid the costs/risks of surgical extraction. We report the design, fabrication, characterization, and validation of a soft, fully bioresorbable, and transparent MEA platform for bidirectional cardiac interfacing over a clinically relevant period. The MEA provides multiparametric electrical/ optical mapping of cardiac dynamics and on-demand site-specific pacing to investigate and treat cardiac dysfunctions in rat and human heart models. The bioresorption dynamics and biocompatibility are investigated. The device designs serve as the basis for bioresorbable cardiac technologies for potential postsurgical monitoring and treating temporary patient pathological conditions in certain clinical scenarios, such as myocardial infarction, ischemia, and transcatheter aortic valve replacement.

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Soft, bioresorbable, transparent microelectrode arrays for multimodal spatiotemporal mapping and modulation of cardiac physiology

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