Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics

Sung Il Park, Daniel S. Brenner, Gunchul Shin, Clinton D. Morgan, Bryan A. Copits, Ha Uk Chung, Melanie Y. Pullen, Kyung Nim Noh, Steve Davidson, Soong Ju Oh, Jangyeol Yoon, Kyung In Jang, Vijay K. Samineni, Megan Norman, Jose G. Grajales-Reyes, Sherri K. Vogt, Saranya S. Sundaram, Kellie M. Wilson, Jeong Sook Ha, Renxiao Xu & 8 others Taisong Pan, Tae Il Kim, Yonggang Huang, Michael C. Montana, Judith P. Golden, Michael R. Bruchas, Robert W. Gereau, John A. Rogers*

*Corresponding author for this work

Research output: Contribution to journalArticle

254 Citations (Scopus)

Abstract

Optogenetics allows rapid, temporally specific control of neuronal activity by targeted expression and activation of light-sensitive proteins. Implementation typically requires remote light sources and fiber-optic delivery schemes that impose considerable physical constraints on natural behaviors. In this report we bypass these limitations using technologies that combine thin, mechanically soft neural interfaces with fully implantable, stretchable wireless radio power and control systems. The resulting devices achieve optogenetic modulation of the spinal cord and peripheral nervous system. This is demonstrated with two form factors; stretchable film appliques that interface directly with peripheral nerves, and flexible filaments that insert into the narrow confines of the spinal epidural space. These soft, thin devices are minimally invasive, and histological tests suggest they can be used in chronic studies. We demonstrate the power of this technology by modulating peripheral and spinal pain circuitry, providing evidence for the potential widespread use of these devices in research and future clinical applications of optogenetics outside the brain.

Original languageEnglish (US)
Pages (from-to)1280-1286
Number of pages7
JournalNature biotechnology
Volume33
Issue number12
DOIs
StatePublished - Dec 1 2015

Fingerprint

Optogenetics
Optoelectronic devices
Equipment and Supplies
Neurology
Fiber optics
Technology
Light sources
Light
Epidural Space
Brain
Chemical activation
Peripheral Nervous System
Modulation
Proteins
Radio
Peripheral Nerves
Control systems
Spinal Cord
Pain
Research

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Molecular Medicine
  • Biomedical Engineering

Cite this

Park, S. I., Brenner, D. S., Shin, G., Morgan, C. D., Copits, B. A., Chung, H. U., ... Rogers, J. A. (2015). Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics. Nature biotechnology, 33(12), 1280-1286. https://doi.org/10.1038/nbt.3415
Park, Sung Il ; Brenner, Daniel S. ; Shin, Gunchul ; Morgan, Clinton D. ; Copits, Bryan A. ; Chung, Ha Uk ; Pullen, Melanie Y. ; Noh, Kyung Nim ; Davidson, Steve ; Oh, Soong Ju ; Yoon, Jangyeol ; Jang, Kyung In ; Samineni, Vijay K. ; Norman, Megan ; Grajales-Reyes, Jose G. ; Vogt, Sherri K. ; Sundaram, Saranya S. ; Wilson, Kellie M. ; Ha, Jeong Sook ; Xu, Renxiao ; Pan, Taisong ; Kim, Tae Il ; Huang, Yonggang ; Montana, Michael C. ; Golden, Judith P. ; Bruchas, Michael R. ; Gereau, Robert W. ; Rogers, John A. / Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics. In: Nature biotechnology. 2015 ; Vol. 33, No. 12. pp. 1280-1286.
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abstract = "Optogenetics allows rapid, temporally specific control of neuronal activity by targeted expression and activation of light-sensitive proteins. Implementation typically requires remote light sources and fiber-optic delivery schemes that impose considerable physical constraints on natural behaviors. In this report we bypass these limitations using technologies that combine thin, mechanically soft neural interfaces with fully implantable, stretchable wireless radio power and control systems. The resulting devices achieve optogenetic modulation of the spinal cord and peripheral nervous system. This is demonstrated with two form factors; stretchable film appliques that interface directly with peripheral nerves, and flexible filaments that insert into the narrow confines of the spinal epidural space. These soft, thin devices are minimally invasive, and histological tests suggest they can be used in chronic studies. We demonstrate the power of this technology by modulating peripheral and spinal pain circuitry, providing evidence for the potential widespread use of these devices in research and future clinical applications of optogenetics outside the brain.",
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Park, SI, Brenner, DS, Shin, G, Morgan, CD, Copits, BA, Chung, HU, Pullen, MY, Noh, KN, Davidson, S, Oh, SJ, Yoon, J, Jang, KI, Samineni, VK, Norman, M, Grajales-Reyes, JG, Vogt, SK, Sundaram, SS, Wilson, KM, Ha, JS, Xu, R, Pan, T, Kim, TI, Huang, Y, Montana, MC, Golden, JP, Bruchas, MR, Gereau, RW & Rogers, JA 2015, 'Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics', Nature biotechnology, vol. 33, no. 12, pp. 1280-1286. https://doi.org/10.1038/nbt.3415

Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics. / Park, Sung Il; Brenner, Daniel S.; Shin, Gunchul; Morgan, Clinton D.; Copits, Bryan A.; Chung, Ha Uk; Pullen, Melanie Y.; Noh, Kyung Nim; Davidson, Steve; Oh, Soong Ju; Yoon, Jangyeol; Jang, Kyung In; Samineni, Vijay K.; Norman, Megan; Grajales-Reyes, Jose G.; Vogt, Sherri K.; Sundaram, Saranya S.; Wilson, Kellie M.; Ha, Jeong Sook; Xu, Renxiao; Pan, Taisong; Kim, Tae Il; Huang, Yonggang; Montana, Michael C.; Golden, Judith P.; Bruchas, Michael R.; Gereau, Robert W.; Rogers, John A.

In: Nature biotechnology, Vol. 33, No. 12, 01.12.2015, p. 1280-1286.

Research output: Contribution to journalArticle

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AU - Brenner, Daniel S.

AU - Shin, Gunchul

AU - Morgan, Clinton D.

AU - Copits, Bryan A.

AU - Chung, Ha Uk

AU - Pullen, Melanie Y.

AU - Noh, Kyung Nim

AU - Davidson, Steve

AU - Oh, Soong Ju

AU - Yoon, Jangyeol

AU - Jang, Kyung In

AU - Samineni, Vijay K.

AU - Norman, Megan

AU - Grajales-Reyes, Jose G.

AU - Vogt, Sherri K.

AU - Sundaram, Saranya S.

AU - Wilson, Kellie M.

AU - Ha, Jeong Sook

AU - Xu, Renxiao

AU - Pan, Taisong

AU - Kim, Tae Il

AU - Huang, Yonggang

AU - Montana, Michael C.

AU - Golden, Judith P.

AU - Bruchas, Michael R.

AU - Gereau, Robert W.

AU - Rogers, John A.

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Park SI, Brenner DS, Shin G, Morgan CD, Copits BA, Chung HU et al. Soft, stretchable, fully implantable miniaturized optoelectronic systems for wireless optogenetics. Nature biotechnology. 2015 Dec 1;33(12):1280-1286. https://doi.org/10.1038/nbt.3415